Protective Effect of Passive Immunization against TNF-α in Infected with Sendai Virus

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概要

• 論文の詳細を見る

• TNF-α has been reported to be induced in mice infected with Sendai virus. We evaluated the role of TNF-α in the virus infection. TNF-α was induced locally in proportion to virus titers in the lung. The activity was correlated with suppression of body weight gain. Passive immunization against TNF-α improved body weight gain and ameliorated pneumonic lesions in infected mice, and prevented them from lethal infection, but lung virus titers were not affected by passive immunization. These results indicate that Sendai virus-induced emaciation, pneumonic lesions and death were mediated by TNF-α.

• 社団法人　日本実験動物学会の論文

著者

• OKADA Hiroyuki

  Department of Gastroenterology/Hepatology, Okayama University Medical School and Graduate School of

• Okada Hiroyuki

  Department Of Cardiology Musashino Red Cross Hospital

• KIRISAWA Rikio

  Department of Veterinary Microbiology, School of Veterinary Medicine, Rakuno Gakuen University

• Kirisawa R

  Rakuno Gakuen Univ. Hokkaido Jpn

• Kirisawa Rikio

  Department Of Veterinary Microbiology School Of Veterinary Medicine Rakuno Gakuen University

• Kirisawa Rikio

  Department Of Epizootiology Faculty Of Veterinary Medicine Hokkaido University

• Obata Yuji

  Department Of Veterinary Microbiology Faculty Of Veterinary Medicine Rakuno Gakuen University

• SHOYA Yuko

  Department of Pathology, National Institute of Infectious Diseases

• Iwai H

  Rakuno Gakuen Univ. Hokkaido Jpn

• Shoya Yuko

  Department Of Pathology National Institute Of Infectious Diseases

• Shoya Yuko

  Department Of Veterinary Microbiology

• IWAI Hiroshi

  Department of Veterinary Microbiology, Faculty of Veterinary Medicine, Rakuno Gakuen University

• MORIOKA Ayako

  Department of Veterinary Microbiology

• GOTO Masamitsu

  Department of Veterinary Microbiology

• YOSHINO Tomo-o

  Department of Veterinary Pathology, Faculty of Veterinary Medicine, Rakuno Gakuen University

• Morioka Ayako

  National Veterinary Assay Laboratory Ministry Of Agriculture Forestry And Fisheries

• Yoshino Tomo-o

  Department Of Veterinary Pathology Faculty Of Veterinary Medicine Rakuno Gakuen University

• Iwai H

  Matsushita Electric Industrial Co. Ltd. Osaka‐shi Jpn

• Iwai Hiroshi

  Department Of Mechanical Engineering Kyoto University

• Iwai Hiroshi

  Department Of Aeronautics And Astronautics Kyoto University

• Okada Hiroyuki

  Department Of Veterinary Pathology Faculty Of Veterinary Medicine Rakuno Gakuen University

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