Nafamostat Mesilate Induces Production of Interleukin-12 and -18 in Human Peripheral Blood Mononuclear Cells
スポンサーリンク
概要
- 論文の詳細を見る
Little has been reported on the drugs inducing production of monocyte-derived cytokines like interleukin (IL)-18 and IL-12. We found that nafamostat mesilate elicits IL-12, IL-18, tumor necrosis factor-α and interferon-γ production, and the expression of intercellular adhesion molecules-1, B7.1, B7.2, CD40, and CD40 ligand in human peripheral blood mononuclear cells. The cytokine production and adhesion molecule expression were abolished by anti-IL-12 and IL-18 antibodies. Therefore, IL-18 and IL-12 may play roles in the significant and immediate effects of nafamostat mesilate.
- 社団法人 日本薬理学会の論文
- 2005-08-20
著者
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YOSHINO Tadashi
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutica
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TANAKA NORIAKI
Department of Surgery, Okayama University School of Medicine
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TAKAHASHI Hideo
Department of Electronics Engineering, Faculty of Engineering, Shibaura Institute of Technology
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NISHIBORI Masahiro
Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceu
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Tanaka Naoko
Department Of Pediatrics Nagoya University School Of Medicine
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Tanaka N
Department Of Gastroenterological Surgery Okayama University Graduate School Of Medicine Dentistry A
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Mori Shuji
School of Pharmacy, University of Shujitsu
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MORI Shuji
Department of Bacteriology, Fukushima Medical College
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Yoshino Tadashi
Dep. Of Pathology Okayama Univ. Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Jp
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Isozaki Hiroshi
Department Of Gastroenterological Surgery Okayama University Graduate School Of Medicine Dentistry A
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Terada N
Department Of Surgery Okayama University School Of Medicine
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Takahashi Hideo
Department Of Pharmacology University Of Okayama Graduate School Of Medicine Dentistry And Pharmaceu
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Mori Shuji
School Of Pharmacy University Of Shujitsu
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Mori Shuji
Department Of Pharmacology Okayama University Graduate School Of Medicine And Dentistry
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Terada N
Department Of Gastroenterological Surgery Okayama University Graduate School Of Medicine Dentistry A
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KATSUNO Goutarou
Department of Gastroenterological Surgery, Transplant, and Surgical Oncology, Okayama University Gra
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IWAGAKI Hiromi
Department of Gastroenterological Surgery, Transplant, and Surgical Oncology, Okayama University Gra
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MIZUNO Kenji
Department of Gastroenterological Surgery, Transplant, and Surgical Oncology, Okayama University Gra
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Mizuno Kenji
Department Of Ecology And Clinical Therapeutics Fukushima Medical University School Of Nursing
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Mizuno Kenji
Department Of Gastroenterological Surgery Transplant And Surgical Oncology Okayama University Gradua
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Iwagaki Hiromi
Department Of Gastroenterological Surgery Okayama University Graduate School Of Medicine Dentistry A
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Tanaka Nobutaka
Department Of Gastroenterology Institute Of Clinical Medicine The University Of Tsukuba
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Yagi Takahito
Department Of Pathology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
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Tanaka Noriaki
Department Of Gastroenterological Surgery Okayama University Graduate School Of Medicine Dentistry A
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Yoshino Tadashi
Department Of Hematology Okayama Rosai Hospital
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Katsuno Goutarou
Department Of Gastroenterological Surgery Transplant And Surgical Oncology Okayama University Gradua
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Mori Shuji
Department Of Bacteriology Fukushima Medical College
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Tanaka Noriaki
Department Of Cardiovascular Physiology Okayama University
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Takahashi H
Department Of Pharmacology Okayama University Graduate School Of Medicine And Dentistry
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Tanaka Naomi
Department Of Gastroenterology Institute Of Clinical Medicine University Of Tsukuba
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Yagi Takahito
Department Of Gastroenterological Surgery Okayama University Graduate School Of Medicine And Dentist
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Mori S
Department Of Pharmacology Okayama University Graduate School Of Medicine And Dentistry
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Nishibori M
Department Of Pharmacology University Of Okayama Graduate School Of Medicine Dentistry And Pharmaceu
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Tanaka Noriaki
Department Of Gastroenterological Surgery Transplant And Surgical Oncology Graduate School Of Medici
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Takahashi Hideo
Department Of Biochemistry School Of Medicine Nihon University
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Takahashi Hideo
Department Of Anatomy Dokkyo Medical University School Of Medicine
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Nishibori Masahiro
Department Of Pharmacology Okayama University Graduate School Of Medicine And Dentistry
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Tanaka Noriaki
Department Of Gastroenterological Surgery Okayama University Graduate School Of Medicine Dentistry A
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Yoshino Tadashi
Department Of Cytopathology Ayabe City Hospital
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Yoshino Tadashi
Department of Chemical Engineering, Hiroshima University
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Iwagaki Hiromi
Department of Gastroenterological Surgery and Transplant, Okayama University Graduate School of Medicine and Dentistry
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