Expression of Wnt5a and β-Catenin in Chinese Oral Squamous Cell Carcinoma of Tongue(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)
スポンサーリンク
概要
- 論文の詳細を見る
Wnt family regulates cell growth, differentiation and proliferation during embryonic development and also plays important roles in tumorigenesis. By the method of immunohistochemistry, a paralleled stydy was conducted to check Wnt5a and β-Catenin expression in OSCC formalin fixed-paraffin embedded tissues. The results demonstrated (1) Wnt5a and β-Catenin cytoplasmic expression appeared in most OSCC. (2) Statistical results showed positive correlation between the level of Wnt5a expression and OSCC differentiation (P<0.05) and inverse correlation between the level of β-Catenin cytoplasmic expression and OSCC differentiation (P<0.05). Cytoplasmic accumulation of β-Catenin protein also associated with lymph node metastasis (P<0.05), and loss of β-Catenin protein on cell membrane was correlative differentiation level of OSCC inversely (P<0.05). These data indicate Wnt/β-Catenin pathway associates with tumorigenesis, metastasis and prognosis of OSCC, and Wnt5a also associates with histological grade of OSCC.
- 硬組織再生生物学会の論文
著者
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Xiao Jing
Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry & Pharmaceutical S
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Zhu En-xin
Department Of Oral Biology College Of Stomatology Dalian Medical University
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Zhu En-xin
Department Of Oral Pathology College Of Stomatology Dalian Medical University
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Xiao Jing
Department Of Oral Biology College Of Stomatology Dalian Medical University
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Li Xiao-ming
Department of Oral Pathology, College of Stomatology, Dalian Medical University
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Zhu Lei
Department of Oral Pathology, College of Stomatology, Dalian Medical University
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Yao Bai-song
Department of Oral Pathology, College of Stomatology, Chinese Medical University
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Xiao Jing
Department Of Oral Pathology College Of Stomatology Dalian Medical University:department Of Oral Pat
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Li Xiao-ming
Department Of Oral Pathology College Of Stomatology Dalian Medical University
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Zhu Lei
Department Of Oral Pathology College Of Stomatology Dalian Medical University
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Zhu Lei
Department Of Nanomaterials And Nanochemistry Hefei National Laboratory For Physical Sciences At Mic
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Yao Bai-song
Department Of Oral Pathology College Of Stomatology Chinese Medical University
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Xiao Jing
Department Of Oral Pathology College Of Stomatology Dalian Medical University:department Of Oral Pat
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Zhu Lei
Department of Clinical Laboratory, 309th Hospital of Chinese People's Liberation Army
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