In Vitro Activity of Linezolid against Clinical Isolates of Mycobacterium tuberculosis, including Multidrug-Resistant and Extensively Drug-Resistant Strains from Beijing, China
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概要
- 論文の詳細を見る
The in vitro activity of linezolid was evaluated against 84 clinical isolates of Mycobacterium tuberculosis, including multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains, isolated from the center for tuberculosis research and treatment of the Chinese army. Linezolid showed excellent activity, with minimum inhibitory concentrations (MICs) of 0.125–0.5 μg/mL against all tested isolates. There were no differences in the MIC50 and MIC90 of linezolid between susceptible, isoniazid-resistant, MDR, and XDR. Indeed, all of the groups displayed identical MIC90 values of 0.25 μg/mL, which is lower than previously reported in similar studies. We conclude that linezolid may be a more effective drug against M. tuberculosis and may play an important role in treating drug-resistant tuberculosis in China.
著者
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He Jufang
Department of Physiology, School of Medicine. The University of Tokushima.
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Zhu Lei
Department Of Nanomaterials And Nanochemistry Hefei National Laboratory For Physical Sciences At Mic
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Dong Mei
Department Of Forensic Medicine Hebei Medical University
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Lei Hong
Department Of Biochemistry And Molecular Biology Beijing Normal University Beijing Key Laboratory
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Wang Di
309th Hospital Of Chinese People's Liberation Army Beijing Chn
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Meng Xianghong
Department of Clinical Laboratory, 309th Hospital of Chinese People's Liberation Army
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Jiang Ying
Department of Clinical Laboratory, 309th Hospital of Chinese People's Liberation Army
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Lei Hong
Department of Clinical Laboratory, 309th Hospital of Chinese People's Liberation Army
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Yang Caie
Department of Clinical Laboratory, 309th Hospital of Chinese People's Liberation Army
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Tong Aihua
Department of Clinical Laboratory, 309th Hospital of Chinese People's Liberation Army
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Yang Caie
Department of Clinical Laboratory, 309th Hospital of Chinese People's Liberation Army
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Tong Aihua
Department of Clinical Laboratory, 309th Hospital of Chinese People's Liberation Army
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Zhu Lei
Department of Clinical Laboratory, 309th Hospital of Chinese People's Liberation Army
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Wang Di
309th Hospital of Chinese People's Liberation Army
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Dong Mei
Department of Clinical Laboratory, 309th Hospital of Chinese People's Liberation Army
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He Jufang
Department of Clinical Laboratory, 309th Hospital of Chinese People's Liberation Army
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