In Vitro Activity of Novel Oxazolidinone Analogs and 13 Conventional Antimicrobial Agents against Clinical Isolates of Staphylococcus aureus in Beijing, China
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概要
- 論文の詳細を見る
Methicillin-resistant Staphylococcus aureus (MRSA) has been a public health concern since it was first identified in the United Kingdom in 1961. In this study, we investigated the prevalence of MRSA in the PLA 309 Hospital located in Beijing, China, and we determined the susceptibility of S. aureus to novel oxazolidinone analogs and 13 conventional antimicrobial agents. It was shown that drug resistant patterns were severe among the clinical isolates, and the average rate of MRSA among the S. aureus strains was 56.3%. All the S. aureus strains tested were completely susceptible to linezolid, but the minimum inhibitory concentration distribution drifted upwards. Among the novel oxazolidinone analogs, sy142 exhibited more potent antimicrobial activity than linezolid against both the standard and clinical S. aureus strains. This observation provides an impetus for the development of potential novel agents based on sy142 in the near future to combat MRSA and linezolid-resistant S. aureus.
著者
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Li Yanyan
Department Of Chemistry Tongji University
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Lei Hong
Department Of Biochemistry And Molecular Biology Beijing Normal University Beijing Key Laboratory
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Gong Ping
Key Lab Of New Drugs Design And Discovery Of Liaoning Province School Of Pharmaceutical Engineering
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Wang Di
Department Of Dermatovenereology Peking University First Hospital
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Jiang Ying
Department of Clinical Laboratory, 309th Hospital of Chinese People's Liberation Army
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Dong Mei
Department of Clinical Laboratory, 309th Hospital of Chinese People's Liberation Army
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Gong Ping
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University
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Dong Yueming
Department of Clinical Laboratory, PLA 309 Hospital
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