Expression of Wnt Signaling Pathway Components in RA-induced Cleft Palate Mouse(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)
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概要
- 論文の詳細を見る
In order to analyze the potential teratogenic mechanism of RA in secondary palate development, we established RA-induced cleft palate (CP) model by using C57BL/6J mice and performed immunohistochemical staining by using Wnt5a, β-Catenin and Bcl-2 antibodies. Higher level expression of Wnt5a was detected in mesenchymal cells of secondary palate at E13 and the expression decreased from E14 in wild type. In RA-induced CP Wnt5a decreased severely at E15 and disappeared earlier. No relative of β-catenin and Wnt5a was detected in both wide type and RA-induced CP mouse. We also found the expression of Bcl-2 located in MEE cells of RA-induced CP group was restrained in horizontal stage of palate development.
- 硬組織再生生物学会の論文
著者
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Xiao Jing
Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry & Pharmaceutical S
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Xiao Jing
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry & Pharmaceutical
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Xiao Jing
Department Of Oral Biology College Of Stomatology Dalian Medical University
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Cong Wei
Department of Oral Biology, College of Stomatology, Dalian Medical University
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Wang Ru
Department of Oral and Maxillofacial Surgery, College of Stomatology, Dalian Medical University
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Hu Hailong
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Huang Hai-tao
Department of Dentistry, the First Affiliated Hospital of Dalian Medical University
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Xiao Jing
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Huang Hai-tao
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Haillong Hu
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Xiao Jing
Department Of Oral Pathology College Of Stomatology Dalian Medical University:department Of Oral Pat
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Xiao Jing
Department Of Oral Pathology College Of Stomatology Dalian Medical University:department Of Oral Pat
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Wang Ru
Department Of Oral And Maxillofacial Surgery College Of Stomatology Dalian Medical University
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Cong Wei
Department Of Oral Biology College Of Stomatology Dalian Medical University
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Huang Hai-tao
Department Of Dentistry The First Affiliated Hospital Of Dalian Medical University
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Hu Hailong
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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Haillong Hu
Department Of Oral Pathology And Medicine Graduate School Of Medicine Dentistry And Pharmaceutical S
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