Positron Emission Tomography/Computed Tomography after Immunocytochemical and Clonal Diagnosis of Intraocular Lymphoma with Vitrectomy Cell Blocks
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概要
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The purpose of this study is to report the role of whole-body 2-[18F] fluoro-2-deoxy-D-glucose (FDG) positron emission tomography fused with computed tomography (PET/CT) after immunocytochemical and clonal diagnosis of intraocular lymphoma with vitrectomy cell blocks. Eleven patients with intraocular lymphoma were involved in this study : 6 patients presented with vitreous opacity in both eyes and 5 patients presented with unilateral involvement. The concurrent retinal lesions were present in 6 eyes of 5 patients. Brain lymphoma was diagnosed in 7 of the 11 patients : simultaneous with eye lesions in one patient, following the eye lesions in 3, and prior to the eye lesions in 3. Vitrectomy was done in 17 eyes of the 11 patients, and vitrectomy cell blocks were processed for immunocytochemical staining and clonality analysis by polymerase chain reaction amplification of the immunoglobulin heavy chain gene. The 7 most recent patients were evaluated with fluorodeoxyglucose whole-body PET/CT. Immunocytochemical staining of vitrectomy cell blocks in all patients showed large cells which were positive for CD20 and Ki-67 but negative for CD3, consistent with diffuse large B-cell lymphoma. The size and sequence of amplified fragments of the immunoglobulin heavy chain gene were different between the lesions of both eyes in one patient while they were the same in another patient. PET/CT after the diagnosis by vitrectomy revealed abnormal uptake in the cerebellum of two patients, in the eye as a recurrent lesion of one patient, and in both eyes as residual retinal lesions of one patient. In conclusion, PET/CT could be considered as a method to confirm brain lymphoma or as a reference for initiating additional therapy in the case of eye recurrence or residual lesions after vitrectomy. The clonality of lymphoma cells was variable between the lesions in both eyes. [J Clin Exp Hematopathol 49(2) : 77-87, 2009]
- 2009-11-01
著者
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Yokozawa Toshiya
豊橋市民病院 血液･腫瘍内科
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Yoshino T
Division Of Pathology Okayama University Hospital
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Yoshida Takashi
Department Of Pathology Okayama University
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Yoshino Tadashi
岡山大学 医歯薬学総合研究科血液･腫瘍･呼吸器･アレルギー内科
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Itoh K
Division Of Oncology And Hematology National Cancer Center Hospital East
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Ichimura Koichi
Department Of Hematology And Rheumatology Tohoku University Graduate School Of Medicine
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Ishizawa K
Department Of Rheumatology And Hematology
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Morito Toshiaki
Department Of Pathology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
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Itoh Kuniaki
Division Of Oncology And Hematology National Cancer Center Hospital East
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Itoh Kuniaki
Hematology And Oncology Division National Cancer Center Hospital East
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Kawase Ichiro
大阪大学 医学系研究科機能診断科学
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Ichimura Koichi
Department Of Pathology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
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Yoshino Tadashi
岡山大学 医歯薬学総合研究科眼科学分野
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Ichimura Koichi
Department Of Pathology Okayama University Graduate School Of Medicine And Dentistry
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Ichimura Koichi
Department Of Pathology And Molecular Diagnostics Aichi Cancer Center
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Ichimura Kouichi
Department Of Pathology Okayama University Medical School And Graduate School Of Medicine Dentistry
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Matsuo Toshihiko
Department Of Ophthalmology Okayama University Medical School And Graduate School Of Medicine Dentis
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Okumura Yoshihiro
Radiology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical Sciences
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Kaji Mitsumasa
Okayama Diagnostic Imaging Center
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ICHIKAWA Tomotsugu
Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical S
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Tadashi Yoshino
Second Department Of Pathology Okayama University Medical School
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Yoshino Tadashi
Department Of Pathology Okayama University
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MATSUO Toshihiko
Ophthalmology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science
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ICHIMURA Kouichi
Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
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YOSHINO Tadashi
Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
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Tamada Yasuhiko
Department Of Dermatology Aichi Medical University Hospital
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Yoshino Tadashi
Department Of Pathology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
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Yoshino Tadashi
Department Of Pathology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
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Yoshino Tadashi
Department Of Pathology And Pathobiology Okayama University Graduate School Of Medicine And Dentistr
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Matsuo Toshihiko
Department Of Ophthalmology Okayama University Graduate School Of Medicine Dentistry And Pharmaceuti
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Yoshino Tadashi
Department Of Pathology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
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Ichikawa Tomotsugu
Neurological Surgery Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical Sciences
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