Metallothioneins and Neurodegenerative Diseases
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概要
- 論文の詳細を見る
A symposium on the clinical aspects of metallothioneins (MTs) in neurodegenerative diseases was held at the 2003 Society of Metallothionein Meeting in Gifu, Japan. The objectives of the symposium were to review and speculate on the potential roles of MTs, especially MT-3 in neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and spinocerebellar degeneration (SCD). Dr. Uchida discussed the controversial problem regarding the expression of MT-3 in AD brains. Dr. Asanuma addressed the function of MTs in the progression of PD and Dr. Hozumi described the therapeutic potential of MTs for ALS, while Dr. Yamada provided immunohistochemical findings of MT-3 in SCD for the first time. Although there are still controversial problems on MTs, this review provides proof that MTs are promising potential therapeutic targets for therapy for some neurodegenerative diseases.
- 社団法人日本薬学会の論文
- 2004-08-01
著者
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YAMADA Mitsunori
Department of Pathology, Brain Research Institute, Niigata University
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HOZUMI Isao
Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine
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Hozumi Isao
Department Of Neurology And Geriatrics Gifu University Graduate School Of Medicine
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Asanuma Masato
Department of Brain Science, Okayama University Graduate School of Medicine and Dentistry
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Uchida Yoko
Gene Expression Research Group, Tokyo Metropolitan Institute of Gerontology
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Asanuma Masato
Department Of Brain Science Okayama University Graduate School Of Medicine And Dentistry
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Asanuma Masato
岡山大学医学部附属分子細胞医学研究施設
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Hozumi Isao
岐阜大学 医研究神経・老年学
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Asanuma M
Okayama Univ. Graduate School Of Medicine And Dentistry Okayama Jpn
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Yamada Mitsunori
Department Of Biology Tokyo Metropolitan University
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Uchida Yoko
Gene Expression Research Group Tokyo Metropolitan Institute Of Gerontology
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