Longitudinal Analysis of Cytokines and Chemokines in the Cerebrospinal Fluid of a Patient with Neuro-Sweet Disease Presenting with Recurrent Encephalomeningitis
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概要
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Background Neuro-Sweet disease (NSD) has recently been identified as Sweet disease with central nervous system (CNS) involvement characterized by multisystem neutrophilic infiltration. However, the pathogenesis of this disease remains unknown. Neutrophil and other inflammatory cell activities are influenced by many cytokines and chemokines, but to date, no studies have examined the levels of these factors in patients with NSD. Patient and Methods The patient presented with encephalomeningitis twice in one year and was diagnosed with NSD. We measured the levels of cytokines (i.e., IL-2, IL-4, IL-6, IL-10, IFN-γ, and TNF-α) and chemokines (i.e., CCL2, CCL3, CCL5, CXCL8, CXCL10 and GM-CSF) in 10 CSF samples from the patient longitudinally for one year including those during two episodes of encephalomeningitis. Results The elevations of IL-6, IFN-γ, CXCL8 (IL8) and CXCL10 (IP10) were markedly higher than the levels in uninfected control subjects with neurological disorders. The levels of these cytokines and chemokines were statistically correlated with total CSF cell counts (p <0.01). Conclusion CD4+ helper T (Th) cells can be divided into the Th1 and Th2 subtypes according to their cytokine secretion patterns, and IFN-γ and IP10 are the Th1-type cytokine and chemokine indicating the involvement of Th1 cells in NSD. In addition, the level of IL8, a specific neutrophil chemoattractant, correlated well with the neutrophil cell counts in CSF. Our data suggest the important roles of Th1 cells and IL8 in the pathogenesis of NSD.
- 社団法人 日本内科学会の論文
著者
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Tanaka Yuji
Department of Molecular and Functional Genomics, Center for Integrated Research in Science, Shimane
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HOZUMI Isao
Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine
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INUZUKA Takashi
Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine
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Hozumi Isao
Dep. Of Neurology And Geriatrics Gifu Univ. Graduate School Of Medicine
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Hozumi Isao
Department Of Neurology And Geriatrics Gifu University Graduate School Of Medicine
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Koumura Akihiro
Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine
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Kimura Akio
Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine
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Sakurai Takeo
Department of Neurology and Geriatrics, Gifu University, Graduate School of Medicine
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Suzuki Yoshihiro
Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine
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Nakajima Hideto
Division of Neurology, First Department of Internal Medicine, Osaka Medical College
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Ichiyama Takashi
Department of Pediatrics, Yamaguchi University School of Medicine
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Ichiyama Takashi
岐阜大学 医学系研究科神経内科老年学分野
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Inuzuka Takashi
Department Of Geriatrics And Neurology School Of Medicine Gifu University
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Ichiyama Takashi
Department Of Pediatrics Graduate School Of Medicine Yamaguchi University
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Sakurai Takeo
Department Of Aeronautical Engineering Faculty Of Engineering Kyoto University
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Tanaka Yuji
Department Of Applied Chemistry Faculty Of Engineering Kyushu Institute Of Technology
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Suzuki Yoshihiro
Department Of Advanced Materials Chemistry Faculty Of Engineering Yokohama National University
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Kimura Akio
Department Of Anesthesiology And Intensive Care Kyoto Prefectural University Of Medicine
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