Beta-Blockers Prevent Cardiac Events in Japanese Patients With Myocardial Infarction
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概要
- 論文の詳細を見る
Background Although the favorable effects of β-blockers in the treatment of myocardial infarction (MI) have been repeatedly demonstrated in Western countries, administration of this drug has been limited in Japan. Methods and Results The study group of 1,896 patients with MI was retrospectively divided into 1,029 patients treated by β-blockers and 867 not treated by β-blockers, and the incidences of cardiac events, consisting of recurrent MI, death because of worsening heart failure, and sudden death, and cardiovascular events, comprising cardiac events and stroke, were compared in both groups. There were 45 cardiac events (4.4%, 30.1 patients/1,000 patients ・ year) among the β-blocker group, which was significantly less than the 56 cardiac events (6.5%, 52.3 patients/1,000 patients・year) among the no-β-blocker group (p<0.05). The total mortality was 92 (8.9%, 61.6 patients/1,000 patients・year) and 124 (14.3%, 115.8 patients/1,000 patients・year), respectively, and cardiac death occurred in 42 (4.1%, 28.1 patients/1,000 patients・year) and 53 (6.1%, 49.5 patients/1,000 patients ・year), respectively, indicating that both these events occurred significantly less in the β-blocker group (p<0.01 and p<0.05). Conclusions Beta-blockers prevent cardiac events in Japanese patients with MI. However, a placebo-controlled, double-blind, multicenter, clinical trial conducted on a large scale in Japan would further contribute more precise information of the useful effects of β-blockers.
- 社団法人日本循環器学会の論文
- 2003-12-20
著者
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Naito Takeo
Department Of Cardiology Kinki University School Of Medicine
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Naito Takeo
Departments Of Cardiology Kinki University School Of Medicine
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Hayashi Takahiro
Division Of Cardiology Department Of Internal Medicine Kinki University School Of Medicine
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Ishikawa Kinji
Division Of Cardiology Department Of Internal Medicine Kinki University School Of Medicine
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Kimura Akio
Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine
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Kimura Akio
Division Of Cardiology Department Of Internal Medicine Kinki University School Of Medicine
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Hayashi Takahiro
Department of Cardiology, Kinki University School of Medicine
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Ishikawa Kinji
Department of Cardiology, Kinki University School of Medicine
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Miyataka Masaru
Department of Cardiology, Kinki University School of Medicine
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Hirano Yutaka
Department of Cardiology, Kinki University School of Medicine
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Takeda Norihiro
Department of Cardiology, Kinki University School of Medicine
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Kanamasa Ken
Department Of Cardiology Kinki University School Of Medicine
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Kanamasa Ken
近畿大学 医学部高血圧・老年内科部門
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Kanamasa Ken
Department Of Vascular And Geriatric Medicine Osaka Japan
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Morishita Masataka
Division Of Cardiology Department Of Internal Medicine Kinki University School Of Medicine
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Kanamasa Ken
Vascular and Geriatric Medicine, Kinki University School of Medicine
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Kimura A
Division Of Cardiology Department Of Internal Medicine Kinki University School Of Medicine
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Hayashi Takahiro
Department Of Cardiology Kinki University School Of Medicine
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Ishikawa K
Division Of Cardiology Department Of Internal Medicine Kashiwara Municipal Hospital
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Hirano Yutaka
Division Of Clinical Laboratory Kinki University Hospital
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Takai Hiroyuki
Division Of Cardiology Department Of Internal Medicine Kinki University School Of Medicine
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Ishikawa Kinji
Department Of Cardiology Kinki University School Of Medicine
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Kimura Akio
Department Of Computer And Information Sciences Faculty Of Engineering Iwate University
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Hirota Takayoshi
Division Of Cardiology Faculty Of Medicine Kinki University
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Hirano Yutaka
Department Of Cardiology Kinki University School Of Medicine
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Kimura Akio
Department Of Anesthesiology And Intensive Care Kyoto Prefectural University Of Medicine
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