Recombinant Tissue Plasminogen Activator Prevents Intimal Hyperplasia After Balloon Anigioplasty in Hypercholesterolemic Rabbits

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概要

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• The purpose of this study was to clarify whether continuous infusion of recombinant tissue plasminogen activator (rtPA) prevents intimal hyperplasia at the site of arterial injury. Forty-three Kurosawa and Kusanagi hyperchloesterolemic (KHC) rabbits which underwent balloon angioplasty of the right common iliac artery were randomly divided into 2 groups; rtPA for 7 days (n=29) and untreated (n=14). The former group was subdivided into a high-dose group (n=15) (2 mg/kg per day continuously for 7 days after 3 mg/kg for 4 h) and a low-dose group (n=14) (0.6 mg/kg per day for 7 days after 0.6 mg/kg for 4 h). Balloon angioplasty was performed with a 2.5-mm balloon (3×60-sec, 6-atm inflations at 60-sec intervals) 1 h after the initiation of rtPA infusion via an ear vein. The iliac arteries of the rabbits were histologically studied at 28 days. The cross-sectional areas of the intima, media, and adventitia were calculated at the site of intimal hyperplasia. The intimal cross-sectional area was 0.07±0.11 (mean±SD) mm^2 for the high-dose rtPA group and 0.11±0.07 mm^2 for the low-dose rtPA group, and both of these values were significantly less than that for the control group (0.57±0.21 mm^2, p<0.01). The ratio of the intimal to medial cross-sectional area was significantly (p<0.01) lower for the rtPA groups than for the control group (high-dose rtPA; 0.10±0.13. low-dose rtPA; 0.21±0.19, control; 1.25±0.55). In conclusion, continuous infusion of rtPA for 7 days prevented intimal hyperplasia after balloon injury.

• 社団法人日本循環器学会の論文
• 1996-10-20

著者

• Ishikawa Kinji

  Division Of Cardiology Department Of Internal Medicine Kinki University School Of Medicine

• Koka H

  First Department Of Internal Medicine Kinki University School Of Medicine

• KATORI Ryo

  First Dept. of Inter. Med Tohoku Univ. School of Med.

• ISHIKAWA Kinji

  First Dept. of Inter. Med Tohoku Univ. School of Med.

• Kondo Hirokazu

  First Department Of Internal Medicine Kinki University School Of Medicine

• KANAMASA Ken

  First Department of Internal Medicine,Kinki University School of Medicine

• Ishida Norihiro

  First Department of Internal Medicine, Kinki University School of Medicine

• Kato Hisaharu

  First Department of Internal Medicine, Kinki University School of Medicine

• Kanamasa Ken

  近畿大学 医学部高血圧・老年内科部門

• Ishikawa Kinji

  First Department Of Internal Medicine Kinki University School Of Medicine

• Katori Ryo

  Showa Hosptial

• Nakabayashi Takayuki

  First Department of Internal Medicine, Kinki University

• Otani Narutaka

  First Department of Internal Medicine, Kinki University

• SAKAMOTO Shigeru

  First Department of Internal Medicine, Kinki University School of Medicine

• Ishida Norihiro

  First Department Of Internal Medicine Kinki University School Of Medicine

• Kato A

  First Department Of Internal Medicine Kinki University

• Sakamoto Shigeru

  First Department Of Internal Medicine Kinki University School Of Medicine

• Katori Ryo

  First Department Of Internal Medicine Kinki University School Of Medicine

• Katori R

  Showa Hosptial

• Otani Narutaka

  First Department Of Internal Medicine Kinki University

• Katori Ryo

  Ist Div. Dept. Of Intern. Med. (prof. T Nakamura) Tohoku University School Of Med. Sendai

• Katori Ryo

  Nakamura Clinic Tohoku University

• Nakabayashi Takayuki

  First Department Of Internal Medicine Kinki University

• Katori Ryo

  The First Department Of Internal Medicine Kinki University School Of Medicine Osaka

• Koka H

  Kinki Univ. School Of Medicine Osaka Jpn

• KANAMASA Ken

  First Department of Internal Medicine, Kinki University School of Medicine

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