Aspirin Plus Either Dipyridamole or Ticlopidine is Effective in Preventing Recurrent Myocardial Infarction

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概要

• 論文の詳細を見る

• The efficacy of combining antiplatelet agents with low doses of aspirin to prevent cardiac events in patients with myocardial infarction was examined. A total of 1,083 patients with prior myocardial infarction were randomly divided into those who were (618) and were not (465) treated with antiplatelet agents, and observed for 12.5±18.5 months. Those treated with antiplatelet agents included 113 patients treated with aspirin (50 mg) plus dipyridamole (150 mg/day), 253 treated with aspirin (50 mg) plus ticlopidine (200 mg/day), and 252 treated with only 1 of the 3 antiplatelet agents. Cardiac events, including fatal or nonfatal recurrent myocardial infarction, death by congestive heart failure, and sudden death, occurred in 34 patients (7.3%) in the nontreatment group and in 19 patients (3.1%: p<0.01) in the treatment group; odds ratio 0.40, 95% confidence interval 0.23-0.71. There were only 2 cardiac events (1.8%) in the aspirin+dipyridamole group (p<0.05 vs nontreatment group: odds ratio 0.28: 0.08-1.03), and 5 such events (2.0%) in the aspirin+ticlopidine group (p<0.01; odds ratio 0.28: 0.11-0.69). Subgroup analysis to exclude differences in the patients' background confirmed the efficacy of these antiplatelet agents. We conclude that combined treatment with low doses of aspirin plus either dipyridamole or ticlopidine is effective in preventing cardiac events in patients who have had prior myocardial infarction.

• 社団法人日本循環器学会の論文
• 1996-12-20

著者

• Naito Takeo

  Department Of Cardiology Kinki University School Of Medicine

• Naito Takeo

  Departments Of Cardiology Kinki University School Of Medicine

• Yamamoto Toshio

  Life Science Institute Kinki University School Of Medicine

• Ishikawa Kinji

  Division Of Cardiology Department Of Internal Medicine Kinki University School Of Medicine

• KATORI Ryo

  First Dept. of Inter. Med Tohoku Univ. School of Med.

• ISHIKAWA Kinji

  First Dept. of Inter. Med Tohoku Univ. School of Med.

• OGAWA Iwao

  Shiroyama Hospital

• YAMAMOTO Tadahiko

  First Department of Internal Medicine, Kinki University School of Medicine

• OGAWA Iwao

  First Department of Internal Medicine,Kinki University School of Medicine

• KANAMASA Ken

  First Department of Internal Medicine,Kinki University School of Medicine

• Naito Takeo

  First Department of Internal Medicine, Kinki University School of Medicine

• Takenaka Toshihiko

  First Department of Internal Medicine, Kinki University School of Medicine

• Kanamasa Ken

  近畿大学 医学部高血圧・老年内科部門

• YAMAMOTO Kentaro

  First Department of Internal Medicine, Kinki University School of Medicine

• Kimura Akio

  First Department of Medicine, Kinki University School of Medicine

• Kanamasa Ken

  Department Of Vascular And Geriatric Medicine Osaka Japan

• Ishikawa Kinji

  First Department Of Internal Medicine Kinki University School Of Medicine

• THE SECONDARY

  the First Department of Medicine, Kinki University School of Medicine

• Katori Ryo

  Showa Hosptial

• Hama Junkichi

  First Department of Internal Medicine, Kinki University School of Medicine

• Nakai Shoji

  First Department of Internal Medicine, Kinki University School of Medicine

• Oyaizu Miki

  First Department of Internal Medicine, Kinki University School of Medicine

• the Secondary

  the Secondary Prevention Group

• Oyaizu Miki

  The first Department of Medicine, Kinki University School of Medicine

• Hama Junkichi

  Department Of Cardiology Sakai Hospital Kinki University School Of Medicine

• Oyaizu Miki

  The First Department Of Medicine Kinki University School Of Medicine

• Yamamoto Kentaro

  First Department Of Internal Medicine Kinki University

• Ogawa Iwao

  Department Of Physics Faculty Of Science Rikkyo University

• Kimura A

  Division Of Cardiology Department Of Internal Medicine Kinki University School Of Medicine

• Katori Ryo

  First Department Of Internal Medicine Kinki University School Of Medicine

• Katori R

  Showa Hosptial

• Nakai Shoji

  First Department Of Internal Medicine Kinki University School Of Medicine

• Hama Junkichi

  The Department Of Cardiology

• Hama Junichi

  Department Of Cardiology Sakai Hospital Kinki University School Of Medicine

• Hama Junkichi

  Department Of Cardiology Kinki University School Of Medicine Sakai Hospital

• The Secondary

  The First Department Of Medicine Kinki University School Of Medicine

• Yamamoto K

  First Department Of Internal Medicine Kinki University

• Hamada Junya

  Department Of Cardiology Kinki University School Of Medicine

• Ogawa I

  Shiroyama Hospital

• Takenaka Toshihiko

  The First Department Of Internal Medicine Kinki University School Of Medicine

• Yamamoto Kentarou

  The First Department Of Internal Medicine Kinki University

• Yamamoto Tadahiko

  First Department Of Internal Medicine Kinki University School Of Medicine

• Yamamoto Tadahiko

  The First Department Of Medicine Kinki University School Of Medicine

• Katori Ryo

  Ist Div. Dept. Of Intern. Med. (prof. T Nakamura) Tohoku University School Of Med. Sendai

• Katori Ryo

  Nakamura Clinic Tohoku University

• Nagata Syuzo

  Kinki University School Of Medicine

• Takenaka Toshihiko

  First Department Of Internal Medicine Kinki University School Of Medicine

• Hama Junkichi

  First Department Of Internal Medicine Kinki University School Of Medicine

• Katori Ryo

  The First Department Of Internal Medicine Kinki University School Of Medicine Osaka

• OGAWA Iwao

  First Department of Internal Medicine, Kinki University School of Medicine

• KANAMASA Ken

  First Department of Internal Medicine, Kinki University School of Medicine

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