Long-Term Nitrate Treatment Increases Cardiac Events in Patients With Healed Myocardial Infarction
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概要
- 論文の詳細を見る
Background Nitrates dilate coronary arteries, ameliorate myocardial ischemia, minimize left ventricular remodeling, and reduce mortality in patients with acute myocardial infarction. However, the effects of long-term treatment with nitrates on cardiac events in patients with healed myocardial infarction are not known. Methods and Results A total of 1, 002 patients with healed myocardial infarction (789 male and 213 female) were randomly divided into 2 groups: treatment with nitrates or nontreatment. The mean observation period was 18.0±19.9 months. Primary end points were nonfatal and fatal recurrent myocardial infarction, death from congestive heart failure, and sudden death. Baseline characteristics of the 2 groups were also compared to determine any effects on outcome. Among the 621 cases treated with nitrates, 41 cases (6.6%) experienced cardiac events during the observation period, whereas only 12 of the 381 cases that were not treated with nitrates (3.1%) had cardiac events. This difference was statistically significant (p<0.05; odds ratio 2.17; 95% confidence interval 1.13-4.19). There were no differences in the incidence of noncardiac death or being lost follow-up between the 2 groups. Although the precise mechanism of this increase in the occurrence of cardiac events by long-term treatment with nitrates is not clear, nitrate tolerance with possible rebound and neurohormanoal effects may be involved. Conclusion Long-term treatment with nitrates increased cardiac events in patients with healed myocardial infarction.
- 社団法人日本循環器学会の論文
- 1996-09-20
著者
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Naito Takeo
Department Of Cardiology Kinki University School Of Medicine
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Naito Takeo
Departments Of Cardiology Kinki University School Of Medicine
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Yamamoto Toshio
Life Science Institute Kinki University School Of Medicine
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Ishikawa Kinji
Division Of Cardiology Department Of Internal Medicine Kinki University School Of Medicine
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OGAWA Iwao
Shiroyama Hospital
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YAMAMOTO Tadahiko
First Department of Internal Medicine, Kinki University School of Medicine
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KATORI RYO
The First Department of Internal Medicine, Kinki University School of Medicine
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YAMAMOTO TADAHIKO
The First Department of Internal Medicine, Kinki University School of Medicine
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KAMATA NORIAKI
First Department of Internal Medicine, Kinki University School of Medicine
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Ishikawa Kinji
The First Depertment of Internal Medicine, Kinki University school of Medicine
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Kanamasa Ken
The First Department of Internal Medicine, Kinki University School of Medicine
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Kimura Akio
The First Department of Internal Medicine, Kinki University School of Medicine
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Kanamasa Ken
近畿大学 医学部高血圧・老年内科部門
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Ishikawa Kinji
The First Department Of Internal Medicine Kinki University School Of Medicine
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TAKENAKA Toshihiko
the First Department of Medicine, Kinki University School of Medicine
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YABUSHITA Hiroshi
the First Department of Medicine, Kinki University School of Medicine
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Katori Ryo
Showa Hosptial
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Ogawa Iwao
The First Department of Internal Medicine, Kinki University
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Nakai Shoji
First Department of Internal Medicine, Kinki University School of Medicine
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Naito Takeo
The first Department of Medicine, Kinki University School of Medicine
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Kamata Noriaki
The first Department of Medicine, Kinki University School of Medicine
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Nakai Shoji
The first Department of Medicine, Kinki University School of Medicine
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Hama Junkichi
The first Department of Medicine, Kinki University School of Medicine
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Oyaizu Miki
The first Department of Medicine, Kinki University School of Medicine
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Yamamoto Kentaro
The first Department of Medicine, Kinki University School of Medicine
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Aso Naoko
The first Department of Medicine, Kinki University School of Medicine
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Arai Miyuki
The first Department of Medicine, Kinki University School of Medicine
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Hama Junkichi
Department Of Cardiology Sakai Hospital Kinki University School Of Medicine
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Oyaizu Miki
The First Department Of Medicine Kinki University School Of Medicine
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Yamamoto Kentaro
First Department Of Internal Medicine Kinki University
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Ogawa Iwao
Department Of Physics Faculty Of Science Rikkyo University
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Kimura A
Division Of Cardiology Department Of Internal Medicine Kinki University School Of Medicine
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Katori R
Showa Hosptial
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Aso Naoko
The First Department Of Medicine Kinki University School Of Medicine
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Katori Ryo
The First Department Of Internal Medicine Kinki University School Of Medicine
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Nakai Shoji
First Department Of Internal Medicine Kinki University School Of Medicine
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Arai Miyuki
The First Department Of Medicine Kinki University School Of Medicine
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Hama Junkichi
The Department Of Cardiology
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Hama Junichi
Department Of Cardiology Sakai Hospital Kinki University School Of Medicine
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Hama Junkichi
Department Of Cardiology Kinki University School Of Medicine Sakai Hospital
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Kamata N
First Department Of Internal Medicine Kinki University School Of Medicine
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Yamamoto K
First Department Of Internal Medicine Kinki University
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Hamada Junya
Department Of Cardiology Kinki University School Of Medicine
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Hirano Yutaka
Division Of Clinical Laboratory Kinki University Hospital
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Ogawa I
Shiroyama Hospital
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Takenaka Toshihiko
The First Department Of Internal Medicine Kinki University School Of Medicine
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Kohashi Noriyuki
First Department Of Internal Medicine Kinki University School Of Medicine
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Yamamoto Kentarou
The First Department Of Internal Medicine Kinki University
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Yamamoto Tadahiko
First Department Of Internal Medicine Kinki University School Of Medicine
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Yamamoto Tadahiko
The First Department Of Medicine Kinki University School Of Medicine
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Katori Ryo
Ist Div. Dept. Of Intern. Med. (prof. T Nakamura) Tohoku University School Of Med. Sendai
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Katori Ryo
Nakamura Clinic Tohoku University
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Nagata Syuzo
Kinki University School Of Medicine
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Takenaka Toshihiko
First Department Of Internal Medicine Kinki University School Of Medicine
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Hama Junkichi
First Department Of Internal Medicine Kinki University School Of Medicine
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Katori Ryo
The First Department Of Internal Medicine Kinki University School Of Medicine Osaka
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