<Originals>Regional blood flow in infarcted myocardium of basic fibroblast growth factor-treated rats

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Several experimental studies have shown that basic fibroblast growth factor (bFGF), when injected intracoronarily in the acutely infarcted myocardium, augments collaterals and reduces infarct size. However, there has been no previous reports on the effects of bFGF on regional myocardial blood flow (Qm) in the infarcted myocardium. We occluded the left coronary artery in 19 SD rats, in 7 of these animals 10μg of bFGF was infused intravenously over 24 hours immediately after coronary occlusion and in the other 12 rats only saline was infused in the same manner. Qm was measured before, immediately after and 4 weeks after occlusion using colored microspheres. In the saline group, Qm was reduced to 9.8±7.6% (mean±SD) of non-infarcted myocardium immediately after coronary occlusion and increased to 17.7±13.2% after 4 weeks. In the bFGF group, Qm was 14.0±6.0% and 22.4±10.0% at these times, respectively. There were no significant differences in Qm at each stage between the two groups. It was concluded that intravenous bFGF did not augment Qm in the infarcted myocardium.
近畿大学の論文