Study on the Biodistribution of Deuterated Biomolecules in Mice Aiming at New Diagnostic Radio-Imaging Agents

概要

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Deuterated compounds (^2H-compounds) labeled with ^<14>C prepared from deuterated algae, Chlorella ellipsoidea, were examined for their time-coursed distribution in mice after intravenous administration. The ^<14>C-^2H-compounds were fractionated and isolated from algae grown in practically 100 mol% ^2H_2O in the presence of ^<14>C-bicarbonate. The fractions obtained were the "basic" and "acid" fractions, composed mainly of amino acids and sugar phosphates, respectively, and glucose, galactose, and lipid fractions. All fractions were examined for their biodistribution in mice bearing Ehrlich solid tumor in comparison with the fractions isolated from ordinary Chlorella (^1H-Chlorella). ^2H-Compounds thus examined showed some behaviors different from ^1H-compounds. The ^2H- "basic" fraction distributed more slowly in heart, lung and liver than the ^1H-fraction. The ^2H-specific large distribution in tumor was also observed on this fraction. The ^2H-dependent characteristics in the distribution of glucose and galactose differed. The ^2H-glucose level was lower in blood and higher in brain, resulting in a brain/blood ratio approximately twice that of ^1H-glucose, while ^2H-galactose did not show such a characteristic. These findings may be useful for the application of ^2H-biomolecules to functional radio-imaging agents for nuclear medicine.
社団法人日本薬学会の論文
1990-09-25