Mechanism of Tumor Transport of ^<99m>Tc-DL-Homocysteine, a Possible Tumor-Imaging Agent

概要

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The mechanism of transport of ^<99m>Tc-DL-homocysteine (^<99m>Tc-Hcy), a possible tumor-imaging agent, was studied. In the blood of mice at 10 min after intravenous injection of ^<99m> Tc-Hcy, most of the radioactivity was distributed in the plasma in both the protein-bound and free forms. The protein-bound form was not appreciably dissociated in physiological saline. Further, when the protein-bound form was injected into tumor-bearing mice, the tumor-distributed radioactivity was about twice that of free ^<99m>Tc-Hcy. The binding protein was considered to be albumin from the result of high performance liquid chromatography analysis. An in vitro experiment showed that the tumor uptake of ^<131>I-albumin was much less than that of ^<99m>Tc-Hcy-albumin. On the other hand, the radioactivity in the tumor cells of ^<99m>Tc-Hcy-injected mice was found to be mostly that of free ^<99m>Tc-Hcy. These results suggest that a portion of the ^<99m>Tc-Hcy ingected was transported to the tumor tissue as an albumin complex in the blood, then released from the albumin and taken up by the cells.
公益社団法人日本薬学会の論文
1988-07-25