Effct of Reticuloendothelial Blockade on Tissue Distribution of ^<99m>Tc-Labeled Synthetic Liposomes in Ehrlich Solid Tumor-Bearing Mice

概要

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The effect of a reticuloendothelial blockade was examined on the tissue distribution of ^<99m>Tc-labeled synthetic liposomes prepared from N, N-didodecyl-N^α-[6-(trimethylammonio)hexanoyl]-L-alaninamide bromide (N^+C_5Ala2C_<12>) in Ehrlich solid tumor-bearing mice.While a pre-dose of unlabeled phosphatidyl choline liposomes (natural liposomes) hardly influenced the tissue distribution of N^+C_5Ala2C_<12> liposomes, the pretreatment of dextran sulfate depressed the uptake in liver accompanied by increasing that in tumor and other tissues except the stomach. However, the extent of liver depression of N^+C_5Ala2C_<12> liposomes by dextran sulfate was lower than that of natural liposomes and the pre-dose of unlabeled natural liposomes had a minor effect on the tissue distribution of N^+C_5Ala2C_<12> liposomes compared with that of natural liposomes. In the liver uptake of N^+C_5Ala2C_<12> liposomes, it was suggested that Kupffer cell phagocytosis was not the main mechanism.
公益社団法人日本薬学会の論文
1991-01-25