クロレラ中のカドミウム結合蛋白質のラット腸管吸収

概要

論文の詳細を見る
The transport of cadmium-binding protein produced in chlorella cells (Ch-CbBP) across rat intestine was in vitro studied using a segment of everted rat small intestine in comparison with CdCl_2. 1) When Ch-CdBP or CdCl_2 was added to the mucosal solution, the transport of Ch-CdBP or CdCl_2 from mucosa to serosa was nearly proportional to the initial Cd concentration and to the incubation time. 2) A significantly higer transport of Cd of Ch-CdBP than that of CdCl_2 was observed but Cd accumulation in the tissue of small intestine was lower in case of Ch-CdBP. 3) It was suggested that Ch-CdBP was transported across rat small intestine without any degradation or change, because Sephadex G-75 gel filtration profile of Cd in the serosal solution after the addition of Ch-CdBP in the mucosal solution was almost identical to gel filtration profile of Ch-CdBP.
公益社団法人日本薬学会の論文
1983-02-28