セレン中毒ラットにおける貧血の機作について : 第2報セレン投与によるビタミンB12の動態および貧血の機作について

概要

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By using rats under selenium poisoning which occurred by repeated administration of sodium selenite and selenate, some studies were conducted to determine the mechanism of anemia caused by selenium dosing.Owing to the results of experiment on the distribution of 57Co-vitamin B12, given subcutaneously and orally, in rats organs and microbioassay of endogenous vitamin B12 in the liver, the deficiency of vitamin B12 in the liver was observed.As a reaction relating to vitamin B12, the formation of 14C-methionine from 14C-methyl folic acid in the supernatant of homogenized liver of poisoned rats was measured, and some decrease resulted. So, the disturbance of transmethylation in the liver caused by selenium poisoning was suggested.In the authors previous paper, the deficiency of iron in the poisoned rat has been reported. Considering the results mentioned above, the abnormality of the metabolism of vitamin B12 and folic acid in the selenium poisoned rat were presumed, and this was presumed to be the cause of the iron deficiency, and accordingly, the anemia.
日本衛生学会の論文