鉛中毒ラット肝の上清分画におけるカルシウム結合成分の存在について

概要

論文の詳細を見る
The behavior of calcium in cytoplasmic soluble fraction in the liver homogenate of rats treated with lead acetate was examined, and the following results were obtained. Lead acetate (Pb 20 mg/100 g) was administered intraperitoneally once to rats. Three days after lead administration, the amount of calcium in the liver of rats increased about 20 times, while in the subcellular fractionation of the tissue, the amount of calcium in cytoplasmic soluble fraction showed an increase of about 40 times compared with normal rats. Cytoplasmic soluble fraction was fractionated by gel filtration. Most of calcium in the liver soluble fraction was bound to macromolecular compound. Six days after lead administration, depletion of calcium from cytoplasmic macromolecular compound was demonstrated. These results suggest that there is a calcium binding component in the liver cytoplasmic soluble fraction of lead-poisoned rats.
公益社団法人日本薬学会の論文
1975-04-30