金属による生体内カルシウム代謝異常の発現
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概要
- 論文の詳細を見る
The action of various metals on calcium metabolism is described in this review. Some metals have a toxic effect on calcium metabolism and its related bone metabolism in mammalian systems. Especially, lead induces hepatic calcium accumulation that is not caused by other heavy metals. This mechanism is based on the action that lead stimulates the mobilization of calcium into blood from bone ; thus lead-induced hypercalcemia stimulates secretion of calcitonin, and hormone causes accumulation of calcium into liver cells. Tin induces calcium accumulation in renal cortex, due to the action that tin increases calcium-binding protein in the cytosol and inhibits Ca-ATPase in the plasma membrane. Such phenomenon is not observed in other metals. Moreover, tin inhibits intestinal calcium transport and increases bile calcium excretion, resulting in hypocalcemia. Zinc produces hypocalcemia, based on the stimulation of gastric calcium secretion mediated through the action of acetylcholine, and the hypocalcemia induces bone resorption related to parathyroid hormone. Cadmium inhibits the stimulation of intestinal calcium transport due to 1,25-dihydroxy vitamin D_3. Also, cadmium directly causes both prevention of bone calcification and stimulation of bone resorption. On the other hand, aluminium is accumulated into bone and reveals a porotic effect. Lithium or manganese causes hypercalcemia. Copper inhibits bone resorption. However, the mechanism of action of these metals is not clarified. Thus action of metals is important as the toxic effect of metals, since disorder of calcium metabolism affects on some physiological functions.
- 公益社団法人日本薬学会の論文
- 1984-04-30
著者
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山口 正義
静岡薬科大学
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山口 正義
Department Of Environmental Biochemistry And Toxicology School Of Pharmaceutical Sciences University
関連論文
- Physiological Significance of Calcium Excretion into the Bile of Rats
- Dietary and Thyroparathyroidal Regulation of Calcium Excretion into the Bile of Rats
- スズ (環境汚染物質と毒性無機物質)
- 微量無機錫を飲水したラットの腎カルシウム増加と血清グルコース低下について
- ラット大腿骨の酸性フォスファターゼとβ-N-アセチルグルコサミダーゼ活性におよぼすカドミウム, 鉛および亜鉛の相互作用
- カドミウム, 鉛および亜鉛投与ラットの大腿骨における蛋白質, Deoxyribonucleic Acid量の変動について
- Immunohistochemical Demonstration of Calcium-Binding Protein Regucalcin in the Tissues of Rats : The protein Localizes in Liver and Brain
- Calcium-Binding Protein Regucalcin Stimulates the Uptake of Ca^ by Rat Liver Mitochondria
- Regucalcin-Induced Ca^ Release from Rat Liver Microsomes : The Effect Is Inhibited by Heparin
- Hepatic Calcium-Binding Protein Regucalcin Decreases Ca^/Calmodulin-Dependent Protein Kinase Activity in Rat Liver Cytosol
- Effects of Ca^, Zn^ and Cd on Uridine Diphosphate-Glucuronyltransferase and β-Glucuronidase Activities in Rat Liver Microsomes
- Effect of the Calcium-Binding Protein Regucalcin on the Ca^ Transport System in Rat Liver Microsomes : The Protein Stimulates Ca^ Release
- Activation of Hepatic Microsomal Ca^-Adenosine Triphosphatase by Calcium-Binding Protein Regucalcin
- Effects of Ca^ and V^ on Glucose-6-phosphatase Activity in Rat Liver Microsomes : The Ca^ Effect Is Reversed by Regucalcin
- Calcium-Binding Protein Regucalcin Is an Activator of (Ca^-Mg^)-Adenosine Triphosphatase in the Plasma Membranes of Rat Liver
- Effects of Ca and Zn on 5'-Nucleotidase Activity in Rat Liver Plasma Membranes : Hepatic Calcium-Binding Protein (Regucalcin) Reverses the Ca Effect
- 鉛中毒ラット肝のカルシウム沈着におよぼすクエン酸ナトリウムの影響について
- 酢酸鉛投与ラットの骨酸性水解酵素活性におよぼすカドミウムの影響について
- Alteration of Glucose Consumption and Adenosine Triphosphate Content in Bone Tissue of Rats with Different Ages : : The Stimulatory Effect of Zinc
- Regulatory Effect of Calcium-Binding protein Isolated from Rat Liver Cytosol on Activation of Fructose 1,6-Diphosphatase by Ca^-Calmodulin
- Physicochemical Properties of Calcium-Binding Protein Isolated from Rat Liver Cytosol : Ca-Induced Conformational Changes
- Calcitonin Increases Succinate Dehydrogenase Activity Dependently on Calcium in the Hepatic Mitochondria of Rats(Biological,Chemical)
- Calcitonin Stimulates Adenosine-5'-triphosphate Synthesis Calcium-Dependently in the Hepatic Mitochondria of Rats(Biological,Chemical)
- Effect of Calcium-Binding Protein on the Activation of Phosphorylase a in Rat Hepatic Participate Glycogen by Ca^(Biological)
- Calcium-Binding Protein Isolated from Rat Liver Cytosol Reverses Activation of Pyruvate Kinase by Ca^(Biological)
- Mitochondrial Uptake of ^Ca^ Bound to Calcium-Binding Protein Isolated from Rat Liver Cytosol
- 金属による生体内カルシウム代謝異常の発現
- 重金属毒性解析の生化学的アプローチ(パネルディスカッション)(第10回環境汚染物質とそのトキシコロジーシンポジウム)
- 無機スズの標的臓器と作用発現
- カルチトニンによる生体内カルシウム調節の機構
- Movement of Subcellular Calcium in the Liver of Bile Duct-ligated Rats
- Zinc Accumulation and Succinate Dehydrogenase Activation in Hepatic Mitochondria of Rats orally Administered Zinc Sulfate
- Zinc Metabolism in the Liver of Rats orally administered Zinc Sulfate
- Calcitonin increases Serum Glucose Concentration independently of Insulin Secretion in Rats
- Properties of Calcium-Binding Protein isolated from the Soluble Fraction of Normal Rat Liver
- 鉛およびカドミウム経口投与ラット肝におけるカルシウムの蓄積について
- 無機スズ経口投与ラットにおける生化学的指標の変動
- 無機スズ経口投与ラットにおける臓内カルシウムの変動
- 無機錫経口投与ラットにおける胆汁カルシウムの上昇
- 鉛およびカルシウムの肝沈着による肝臓アルカリ性フォスファターゼ活性の慢性的な阻害について
- 鉛中毒ラット肝の上清分画におけるカルシウム結合成分の存在について
- 鉛中毒ラットのポルフィリン代謝について自動車排気成分による複合的影響
- 鉛中毒ラットにおけるカルシウム代謝について
- 鉛中毒ラットのポルフィリン代謝について : 鉛含有粉じん曝露実験
- 鉛中毒ラット肝におけるカルシウムの沈着について
- ラット大腿骨中カルシウム量におよぼすカドミウム, 鉛および亜鉛の相互作用について
- 無機錫中毒ラットにおけるビタミンD3の血清カルシウム上昇作用の阻害について
- 無機錫経口投与ラットにおける胃酸分泌の低下
- 無機錫中毒ラットのカルシウム代謝障害の発現に対する鉛の影響
- 酢酸鉛投与ラットの肝切片におけるカルシウム流出におよぼすカルチトニンの影響について
- 鉛中毒ラット肝におけるカルシウム蓄積の機構について
- 鉛中毒ラットにおける骨カルシウムの血清への動員について
- 鉛中毒ラット肝の核分画における鉛とカルシウムの結合について