無機錫経口投与ラットにおける胆汁カルシウムの上昇

概要

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The effect of stannous chloride on the bile calcium concentration in rats was examined in these experiments. The bile calcium concentration in rats that had fasted for 2 hours was significantly increased by a single oral administration of tin (3.0mg/100g body weight). An oral administration of tin to rats elevated the bile calcium concentration with three doses (1.0, 3.0 or 5.0mg of Sn/100g) of tin employed. Also, the bile calcium concentration and bile volume showed a significant increase in rats administered orally with tin (3.0mg/100g) during 3 days. On the other hand, the increased bile volume produced by the treatment of tin reduced to the control level at 66 hours after the orall administration with tin during 3 days, while the bile calcium concentration increased significantly. This fact indicates that the augmentation of blie calcium concentraion after the administration of tin is not related to the elevation of bile volume.
日本衛生学会の論文