鉛中毒ラットにおける骨カルシウムの血清への動員について

概要

論文の詳細を見る
The concentration of calcium in serum, and the amount of lead and calcium in femur of rats were determined after a single intraperitoneal administration of lead acetate, and the following results were obtained. In the case of administration of lead acetate, zinc acetate, stannous acetate, manganese acetate, or calcium acetate (0.483 mmole/kg as metal ion), lead acetate significantly increased the serum calcium concentration compared to that of other metals. Lead deposition in femur increased rapidly and reached a maximum 2 days after administration of lead (0.965 mmole/kg as metal ion). On the other hand, the amount of calcium in femur decreased by about 15% (p<0.05) of the control values one day after lead administration. The data obtained from the present experiments agree with the view that the increase of serum calcium induced by the administration of lead is caused by release of calcium into serum from the bone.
公益社団法人日本薬学会の論文
1974-10-31