ラット大腿骨の酸性フォスファターゼとβ-N-アセチルグルコサミダーゼ活性におよぼすカドミウム, 鉛および亜鉛の相互作用

概要

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The acid phosphatase and β-N-acetylglucosaminidase activities of femur were examined in rats intraperitoneally administered cadmium acetate, lead acetate, zinc acetate, or combined metals (0.89 μmol as a metal ion/100 g body weight) 5 times at 2-day intervals. Acid phosphatase activity in the diaphysis was significantly decreased by the administration of cadmium and increased by the injection of lead or zinc compared with that of normal rats, but this enzyme activity in the epiphysis was significantly elevated by cadmium alone. Also, β-N-acetylglucosaminidase activity in the diaphysis was significantly reduced by the administration of cadmium or zinc and enhanced by the treatment with lead compared with that of normal rats, but this enzyme activity in the epiphysis was significantly increased by cadmium alone. On the other hand, these enzyme activities in both diaphysis and epiphysis after injection of combined metals did not show a significant alteration. The present results indicate that the specific action of each metal was modified by the administration of these metals in combination.
公益社団法人日本薬学会の論文
1977-08-31