Effects of Various Calcitonins on Calcium Concentrations in the Bile and Serum of Thyroparathyroidectomized Rats

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The effects of porcine calcitonin (CT), salmon CT, or synthetic eel CT ( [Asu^<1,7>] ECT) on the calcium concentrations in the bile and serum have been examined after a single intraperitoneal administration of calcium chloride to thyroparathyroidectomized rats. The administration of these hormones (80 MRC mU/100 g body weight, respectively) markedly increased calcium excretion into the bile within 1 hr after the injection of calcium chloride (4.0 mg Ca/100 g). The effect of synthetic eel CT was more prolonged than that of any other hormone (up to 3 hr after administration). The administration of porcine CT, salmon CT, or synthetic eel CT significantly inhibited the elevation of serum calcium concentration within 1 hr after the injection of calcium. The serum calcium concentration was slightly decreased at 3 hr after the administration of salmon CT or synthetic eel CT. These results suggest that the lowering effect of CT on the serum calcium level results partly from the stimulation of calcium excretion into the bile.
公益社団法人日本薬学会の論文
1979-07-25