The Increase of Acid Hydrolases Activity in Bone Tissue of Rats Treated with Lead Acetate

概要

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The effect of a single intraperitoneal administration of lead acetate on acid hydrolases activity in bone tissues of rat was studied. The administration of lead to rats produced a persistent increase in acid phosphatase activity, while alkaline phosphatase activity decreased. There was a significant increase in β-glucuronidase, β-N-acetylglucosaminidase, and β-galactosidase activities in bone tissues as early as 1 day after lead administration. These enzymes activity, at three dose levels (5,10,and 20 mg lead per 100 g body weight), significantly increased when compared with the values obtained from rats received control injection with distilled water. In the present study, it is demonstrated that the administration of lead could cause an increase in lysosomal acid hydrolases activity in the bone tissues of rat.
公益社団法人日本薬学会の論文
1975-08-25