無機錫中毒ラットのカルシウム代謝障害の発現に対する鉛の影響

概要

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The effect of lead acetate (Pb; 25.3μmole/100g body weight) on the kidney calcium accumulation, the decreased serum calcium concentration, and the increased serum inorganic phosphorus concentration induced by the administration of stannous chloride (Sn; 25.3μmole/100g) was studied. The predominent kidney calcium accumulation, the decreased serum calcium and the increased serum inorganic phosphorus concentrations produced at 72 hours after a single intraperitoneal administration of stannous chloride was significantly inhibited when lead acetate was administered 24 hours before the administration of stannous chloride or at the same time. On the other hand, when lead acetate was administered 24 houres after the administration of stannous chloride, lead had no effect on revelation of calcium metabolic disturbance in rats treated with stannous chloride. The data obtained from the present experiments suggest that the lead acted antagonistically on the accumulation of tin into the kidney cells and inhibited the manifestation of the renal effect by tin.
日本衛生学会の論文