セレン中毒ラットにおける貧血の機作について : 第1報セレン投与による貧血および鉄の動態について

概要

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Sodium selenite solution (3.0mg/kg) and sodium selenate solution (3.2mg/kg) were repeatedly given to 2 groups of rats orally, once a day and once every other day, respectively, for 35 days.As the general symptoms of selenium poisoning, suppression of growth, loss of hair, etc. were observed. By dissection and histological observation, disorders of liver and kidney were found and some characteristics of anemia were noted by hematological test and microscopic survey of bone marrow cells.In order to study the mechanism of the anemia caused by selenium dosing, the accumulation of injected 59Fe-ferric chloride to organs, the iron binding capacity of serum and influence on the production of heme were investigated using rats under selenium poisoning.Concerning the turnover of iron, increase of the incorporation of injected 59Fe to red blood cells and rise of the total and unsaturated iron binding capacity of serum were observed, so it was thought that the prominent cause of the selenium poisoning might be the insufficiency of iron. Furthermore, increase of the porphyrin metabolites in urine and decrease of the incorporation of injected 14C-glycine to heme were observed, as the related phenomenons to iron defficiency.
日本衛生学会の論文