Metabolic Fate of 2,5-Dimethoxy-4-methylamphetamine in the Guinea Pig and Rabbit

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Metabolic fate of 2,5-dimethoxy-4-methylamphetamine (DOM) was investigated in the guinea pig and rabbit. DOM concentration in serum decreased rapidly after a subcutaneous injection and DOM was scarcely obtained at 3 to 4 hours later by radioimmunoassay and thin-layer chromatography. As the metabolites of DOM, 2,5-dimethoxy-4-hydroxymethylphenyl-2-aminopropane and 2,5-dimethoxy-4-carboxyphenyl-2-aminopropane were confirmed in the urine of guinea pig and rabbit. 2,5-Dimethoxy-4-methylphenyl-2-propanol and 2,5-dimethoxy-4-methylphenyl-2-propanone, which had not been detected in rat urine but in the incubation mixture of DOM with rabbit liver microsome, were identified in guinea pig and rabbit urines. 2,5-Dimethoxy-4-methylbenzoic acid was firstly detected as a minor metabolic product of DOM in the urine of both species of animals. Principal metabolic pathway of DOM in guinea pig was not regarded as the side-chain oxidation but as the oxidation of methyl group on benzene ring as well as in rabbit.
公益社団法人日本薬学会の論文
1978-04-25