セレン化合物の衛生化学的研究(第5報)セレン投与ラットの尿および肝の代謝物について

概要

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Fraction of urine and supernatant of liver homogenate of a rat, administered sodium ^<75>Se-selenite or sodium ^<75>Se-selenate solution orally, was achieved by anion exchange resin column chromatography, in order to know the ratio of organic metabolite fraction and inorganic metabolite fraction. The metabolites in the organic fraction of urine was identified and determined. Organic metabolite was prominently excreted after either single or repeated oral administration, and it was 70-80% of all radioactivity in the urine. A similar result was obtained in the analysis of the supernatant of liver homogenate. On the composition of the organic selenium metabolite, dimethylselenoxide and trimethylseleno compound were identified and their amounts were about 55% and 10% of the total metabolite, respectively.
社団法人日本薬学会の論文
1977-10-31