セレン化合物の衛生化学的研究(第3報)亜セレン酸ナトリウムの母体内分布と胎仔への移行, 分布について

概要

論文の詳細を見る
Pregnant rats were used for experiment at 20 th day after gestation, which was determined by the presence of a vaginal plug after mating. Sodium selenite[^<75>Se]solution was given intravenously to a number of pregnant rats and the distribution pattern of ^<75>Se in the mother and fetus was determined by measuring radioactivities 1 hr after injection. In the mother rats, high concentration of ^<75>Se was found in the liver, kidney, pancreas and lung, the concentration being twice higher than that in the blood. The transfer of ^<75>Se to fetus was not so marked but radioactivity 5% of the dose was found in the whole body of a litter. High concentration of ^<75>Se was observed in the liver, adrenal and kidney of the fetuses, concentration of ^<75>Se in the bone, spleen and gastro-intestinal tract was the same as that in the whole body of fetuses.
社団法人日本薬学会の論文
1974-12-31