食品添加物の放射線分解(第1報)水溶液中におけるソルビン酸の放射線分解と照射ソルビン酸水溶液の抗菌性について

概要

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Aqueous solution of sorbic acid (0.32 mg %) was irradiated with ^<60>Co γ-ray (dose rate 2.48×10^4 rad/hr) in doses ranging from 0 to to 2.175×10^4 rad, and decomposition of the acid was examined by spectrophotometry. Absorbance at λ max 255 nm due to sorbic acid decreased with increasing radiation dose and the G (-sorbic acid) value was calculated from the decreasing rate of the absorbance to give 1.85. An aqueous solution of sorbic acid irradiated at the dose 7×10^5-13×10^5 rad showed a stronger antibacterial activity than non-irradiated solution against E. coli, in spite of the decrease of sorbic acid in the solution. Therefore, new antibacterial substance was assumed to have been produced in the solution by γ-ray irradiation. This irradiated solution also showed antibacterial activity against 5 other kinds of bacteria. It was also proved that the presence of O_2 gas might be essential for the production of the new antibacterial substnce by experiments on antibacterial activity of irradiated solutions sealed with or without O_2 gas.
公益社団法人日本薬学会の論文
1972-10-31