医薬品の放射線殺菌 II : クロロフィル製剤の放射線殺菌その2

概要

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Effects of ^<60>Co γ-rays irradiation on the median lethal dose, leukocyte mobilizing action and other pharmacological properties of chlorophyll derivatives were studied using male mice (DDY strain) and rabbits. Cu-chlorophyll, M-Co-chloropyll and DBI-Co-chlorophyll in solid state were irradiated with 3 Mrad ^<60>Co γ-rays. The median lethal dose of the irradiated and nonirradiated Cu-chlorophyll by the intraperitoneal injection was determined to be 0.773±0.016 mg/g (body weight of mouse) and 0.769±0.016 mg/g, respectively. Intravenous administration of chlorophyll derivatives to normal rabbits caused a remarkable leukocytosis (mainly due to neutrophilia) at 3 to 5 hours after injection, and no significant difference in the leukocyte mobilizing action between the irradiated and nonirradiated samples was observed. From these results, the possibility of practical application of radiation to the sterilization of drugs was discussed.
公益社団法人日本薬学会の論文
1966-08-30