セレン化合物の衛生化学的研究(第6報)セレン投与のラット生体内鉄およびコバルトにおよぼす影響

概要

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Determination of iron and cobalt content in blood, serum, liver, spleen, kidneys, and bone of rats, administered sodium selenite and sodium selenate repeatedly, was performed by atomic absorption spectrophotometry. By the influence of selenium dosing, the content of iron decreased in blood, serum, liver, and spleen. Especially, the content in the groups given selenite and selenate decreased to about 50% and 40% of control group in spleen, and about 70% and 60% in serum, respectively. The decrease of cobalt content was observed in blood, liver, and bone. It decreased to about 30% of control group in blood of selenite group, and about 80% in liver of both treated groups. These results indicated that the dose of selenium compounds might affect the normal metabolism of these important metals.
社団法人日本薬学会の論文
1977-10-31