無機スズ経口投与ラットにおける生化学的指標の変動

概要

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The toxic effect of orally administered tin compounds was examined in rats. Stannous chloride and concentrated solution of tin eluted from canned citric acid (can-tin solution) were used. The latter is a model compound of tin from canned food. The rats were administered with the compounds, at a dose of 30 mg Sn/kg at each time, 6 times at 12 hr intervals, and then bled 17 hr after the last administrotion. Both compounds caused femoral deposition of tin. The deposition was also found in the stomach only after stannous chloride. Of the biochemical markers tested, gastric acid secretion, duodenal alkaline phosphatase activity, serum calcium concentration, hepatic phosphorylase activity, and femoral calcium content were significantly reduced by the administration of stannous chloride. On the other hand, only femoral calcium content was significantly decreased by can-tin solution. These results suggest that, in the experimental condition of the present study, bone is the target organ of inorganic tin compounds, possibly, in any chemical form.
公益社団法人日本薬学会の論文
1979-10-31