Regucalcin-Induced Ca^<2+> Release from Rat Liver Microsomes : The Effect Is Inhibited by Heparin
スポンサーリンク
概要
- 論文の詳細を見る
The effect of heparin on the calcium-binding protein regucalcin-stimulated Ca^<2+> release from rat liver microsomes was investigated. Ca^<2+> release was assayed by the method of Millipore filtration to estimate microsomal ^<45>Ca^<2+> accumulation following the addition of 10 mM adenosine triphosphate. The addition of regucalcin (1.0 μM) or inositol 1,4,5-trisphosphate [Ins(1,4,5)P_3; 1.0 μM] stimulated ^<45>Ca^<2+> release from rat liver microsomes. These effects were completely inhibited by the presence of heparin (10.0 μg/ml). Regucalcin did not enhance the effect of Ins(1,4,5)P_3. These results suggest that regucalcin affects ^<45>Ca^<2+> release involved in Ins(1,4,5)P_3 action in rat liver microsomes.
- 公益社団法人日本薬学会の論文
- 1990-08-25
著者
-
森 聖一
Department Of Environmental Biochemistry School Of Pharmaceutical Sciences University Of Shizuoka
-
山口 正義
Department of Environmental Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka
-
山口 正義
Department Of Environmental Biochemistry And Toxicology School Of Pharmaceutical Sciences University
-
山口 正義
静岡県立大学 大学院
-
山口 正義
静岡県立大学薬学部
関連論文
- IGF-Iの骨芽細胞(MC3T3-E1)機能促進作用が亜鉛により増強される
- ワサビ抽出物の骨代謝機能に対する影響
- Physiological Significance of Calcium Excretion into the Bile of Rats
- Dietary and Thyroparathyroidal Regulation of Calcium Excretion into the Bile of Rats
- スズ (環境汚染物質と毒性無機物質)
- ラット腎皮質に局在する新規Ca^結合蛋白質レギュカルチンの遺伝子発現とそのCa^/カルモデュリン依存性酵素活性の制御
- 骨組織培養系における納豆由来メナキノン-7の効果
- Effect of Insulin Administration on Bone Formation Is Impaired in Rats with Skeletal Unloading
- Oral Administration of Calcium Hydroxide Stimulates Bone Metabolism in the Femoral Diaphysis of Rats with Skeletal Unloading
- Immunohistochemical Demonstration of Calcium-Binding Protein Regucalcin in the Tissues of Rats : The protein Localizes in Liver and Brain
- Calcium-Binding Protein Regucalcin Stimulates the Uptake of Ca^ by Rat Liver Mitochondria
- Regucalcin-Induced Ca^ Release from Rat Liver Microsomes : The Effect Is Inhibited by Heparin
- Hepatic Calcium-Binding Protein Regucalcin Decreases Ca^/Calmodulin-Dependent Protein Kinase Activity in Rat Liver Cytosol
- Effects of Ca^, Zn^ and Cd on Uridine Diphosphate-Glucuronyltransferase and β-Glucuronidase Activities in Rat Liver Microsomes
- Effect of the Calcium-Binding Protein Regucalcin on the Ca^ Transport System in Rat Liver Microsomes : The Protein Stimulates Ca^ Release
- Activation of Hepatic Microsomal Ca^-Adenosine Triphosphatase by Calcium-Binding Protein Regucalcin
- Effects of Ca^ and V^ on Glucose-6-phosphatase Activity in Rat Liver Microsomes : The Ca^ Effect Is Reversed by Regucalcin
- Calcium-Binding Protein Regucalcin Is an Activator of (Ca^-Mg^)-Adenosine Triphosphatase in the Plasma Membranes of Rat Liver
- Effects of Ca and Zn on 5'-Nucleotidase Activity in Rat Liver Plasma Membranes : Hepatic Calcium-Binding Protein (Regucalcin) Reverses the Ca Effect
- 生体必須元素亜鉛の骨代謝調節における役割と骨病態修復
- ラット骨折修復におけるアセキサム酸亜鉛の促進効果
- 骨代謝調節における亜鉛の役割-亜鉛はβクリプトキサンチンの骨同化効果を増強する
- レギュカルチントランスジェニックラットの生活習慣病モデル動物としての有用性
- イソフラボンによる破骨細胞様細胞の抑制とカルシウム依存性
- イソフラボンによる骨芽細胞様細胞(MC3T3-E1)機能の調節
- 加齢ラット皮質骨組織培養系におけるイソフラボンの骨同化効果の発現
- アセキサム酸亜鉛は加齢ラット骨組織培養系で強い骨形成促進作用を発現する
- 植物性エストロゲン(ゲニステイン)の骨組織培養系における骨形成と骨吸収に対する作用
- ラット大脳組織中カルシウム動態の調節-加齢による影響-
- ラット肝再生時における細胞膜(Ca^-Mg^)-ATPase活性の上昇-Ca^シグナリングの制御蛋白質レギュカルチンによる調節
- 亜鉛の骨形成促進因子としての役割
- Alteration of Glucose Consumption and Adenosine Triphosphate Content in Bone Tissue of Rats with Different Ages : : The Stimulatory Effect of Zinc
- Regulatory Effect of Calcium-Binding protein Isolated from Rat Liver Cytosol on Activation of Fructose 1,6-Diphosphatase by Ca^-Calmodulin
- 納豆含有ビタミンK2(メナキノン-7)の骨粗鬆症における予防的役割
- 亜鉛と骨 (特集 亜鉛と臨床)
- Comparison of the Effect of β-Alanyl-L-histidinato Zinc and Its Zinc-Chelating Ligand on Bone Metabolism in Tissue Culture
- レギュカルチン(Regucalcin) (カルシウムイオンを介した調節機構の新しい問題点) -- (新しいカルシウム結合蛋白質)
- Physicochemical Properties of Calcium-Binding Protein Isolated from Rat Liver Cytosol : Ca-Induced Conformational Changes
- Calcitonin Increases Succinate Dehydrogenase Activity Dependently on Calcium in the Hepatic Mitochondria of Rats(Biological,Chemical)
- Calcitonin Stimulates Adenosine-5'-triphosphate Synthesis Calcium-Dependently in the Hepatic Mitochondria of Rats(Biological,Chemical)
- Effect of Calcium-Binding Protein on the Activation of Phosphorylase a in Rat Hepatic Participate Glycogen by Ca^(Biological)
- Calcium-Binding Protein Isolated from Rat Liver Cytosol Reverses Activation of Pyruvate Kinase by Ca^(Biological)
- Mitochondrial Uptake of ^Ca^ Bound to Calcium-Binding Protein Isolated from Rat Liver Cytosol
- 金属による生体内カルシウム代謝異常の発現
- 重金属毒性解析の生化学的アプローチ(パネルディスカッション)(第10回環境汚染物質とそのトキシコロジーシンポジウム)
- 無機スズの標的臓器と作用発現
- カルチトニンによる生体内カルシウム調節の機構
- Movement of Subcellular Calcium in the Liver of Bile Duct-ligated Rats
- Zinc Accumulation and Succinate Dehydrogenase Activation in Hepatic Mitochondria of Rats orally Administered Zinc Sulfate
- Zinc Metabolism in the Liver of Rats orally administered Zinc Sulfate
- Calcitonin increases Serum Glucose Concentration independently of Insulin Secretion in Rats
- Properties of Calcium-Binding Protein isolated from the Soluble Fraction of Normal Rat Liver