骨組織培養系における納豆由来メナキノン-7の効果

概要

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Menaquinone-7(MK-7) and phylloquinone (vitamin K_1), which are vitamin K homologues n foods, were purified from the fermented soybean (natto) and soybean, respectively. The effect of MK-7 and K_1 in the metaphyseal tissues obtained from rat femur in vitro was investigated. Bone tissue was cultured for 24 or 48 hr in the presence or absence of MK-7 in the range of 10^<-7> to 10^<-5> M. The presence of MK-7(10^<-5>M) caused a significant increase of calcium content and alkaline phosphatase (ALP) activity in the bone tissue. Bone DNA content and bone glucose consumption were not changed by the addition of MK-7(10^<-5>M). Meanwhile, the presence of MK-4(10^<-5>M) caused a significant increase of ALP activity in the bone tissue, while K_1(10^<-5>M) did not have the effect .These results suggest that MK-7 can directly act on the femoral metaphyseal tissues of rat femur in vitro.
日本ビタミン学会の論文
1996-07-25