Alteration of Glucose Consumption and Adenosine Triphosphate Content in Bone Tissue of Rats with Different Ages : : The Stimulatory Effect of Zinc
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概要
- 論文の詳細を見る
The alteration in bone metabolism at different ages was investigated by estimating glucose consumption and adenosine triphosphate (ATP) content in a culture system of bone tissue from 3- and 30-week-old rats. The femoral-diaphyseal tissue was removed and cultured for periods up to 48 h in Dulbecco's Modified Eagle Medium. Bone tisse was incubated at 37℃ in 5% CO_2/95% air in a medium containing either vehicle and zinc sulfate (10^<-6>-10^<-4>M). The medium glucose consumed by bone tissue clearly increased in a 48 h-culture in 3-week-old rats, while the increase in 30-week-old rats was slight. The presence of zinc culfate (10^<-6> and 10^<-5>M) caused a significant increase in bone glucose consumption in 3- and 30-week-old rats. ATP content in cultured bone tissue from 30-week-old rats fairly fell in comparison with that from 3-week-old rats. Bone ATP contents in 3- and 30-week-old rats were significantly increased by the presence of zinc (10^<-4>M). The present findings suggest that bone energy metabolism deteriorates with increasing age, and that zinc has a stimulatory effect in elderly rats.
- 公益社団法人日本薬学会の論文
- 1990-06-25
著者
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祐田 泰延
Department of Environmental Biochemistry and Toxicology, University of Shizuoka School of Pharmaceut
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山口 正義
Department of Environmental Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka
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山口 正義
Department Of Environmental Biochemistry And Toxicology School Of Pharmaceutical Sciences University
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祐田 泰延
University Of Shizuoka School Of Pharmaceutical Sciences Department Of Environmental Biochemistry An
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尾崎 加代子
Department of Environmental Biochemistry and Toxicology, School of Pharmaceutical Sciences, Universi
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Suketa Yasunobu
Department Of Environmental Biochemistry And Toxicology University Of Shizuoka School Of Pharmaceuti
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尾崎 加代子
Department Of Environmental Biochemistry And Toxicology School Of Pharmaceutical Sciences University
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