Acceptor Specificity in the Glucosylation Reaction of Bacillus subtilis X-23 α-Amylase towards Various Phenolic Compounds and the Structure of Kojic Acid Glucoside
スポンサーリンク
概要
- 論文の詳細を見る
The transglucosylating reaction of the α-amylase (HGE) from Bacillus subtilis X-23 was studied using various phenolic compounds, catechins, and kojic acid as acceptors. Among them, hydroquinone, resorcinol, catechol, catechins, and kojic acid were glucosylated with high efficiency by HGE. In glucosylating kojic acid, kojic acid monoglucoside was accumulated at the end of the reaction. Analysis of the structure of kojic acid glucoside by ^1H-NMR and ^<13>C-NMR indicated that glucose was transferred to the hydroxymethyl group of kojic acid and that the resultant compound was glucopyranosyl-α-O-2-methyl-5-hydroxy-γ-pyrone. Comparing kojic acid and kojic acid glucoside, the solubility of the glucoside was about ten times that of aglucone. In addition, the stability of kojic acid was improved by glucosylation.
- 社団法人日本生物工学会の論文
- 1994-07-25
著者
-
NISHIMURA Takahisa
Biochemical Research Laboratory, Ezaki Glico Co., Ltd.
-
Tanimoto H
Ajinomoto Co. Inc. Kawasaki Jpn
-
Okada S
School Of Pharmaceutical Sciences University Of Shizuoka
-
Kometani T
Biochemical Res. Lab. Ezaki Glico Co. Ltd.
-
Kuriki T
Ezaki Glico Co. Ltd. Osaka Jpn
-
Kometani Takashi
Biochemical Research Laboratory, Ezaki Glico Co., Ltd.
-
Takii Hiroshi
Biochemical Research Laboratory, Ezaki Glico Co., Ltd.
-
Terada Yoshinobu
Biochemical Research Laboratory, Ezaki Glico Co., Ltd.
-
Okada Shigetaka
Biochemical Research Laboratory, Ezaki Glico Co., Ltd.
-
To-o Kenji
Health Science Laboratory Ezaki Glico
-
Kuriki Takashi
Biochemical Research Laboratories Ezaki Glico Co. Ltd.
-
Nishimura Takahisa
Biochemical Research Laboratory Ezaki Glico Co. Ltd.
-
Takii H
Biochemical Research Laboratory Ezaki Glico Co. Ltd.
-
Nakae Takashi
Biochemical Research Laboratory Ezaki Glico Co. Ltd.
-
Nishimura T
Biochemical Research Laboratory Ezaki Glico Co. Ltd.
-
Kometani Takashi
Biochemical Research Laboratory Ezaki Glico Co. Ltd.
-
Okada Shigetaka
Biochemical Research Laboratory Ezaki Glico Co. Ltd.
-
Terada Y
Biochemical Research Laboratory Ezaki Glico Co. Ltd.
-
Terada Yoshinobu
Biochemical Research Laboratory Ezaki Glico Co. Ltd.
-
Terada Yoshinobu
Research Institute For Food Science Kyoto University
-
TAKII Hiroshi
Biochemical Research Laboratory, Ezaki Glico Co. Ltd.
関連論文
- α-アルブチンの開発 : 工業スケールでの製造および美白化粧品原料への応用
- Experimental study on cross-reactivity of α-arbutin toward p-phenylenediamine and hydroquinone in guinea pigs
- リポソーム化 CNDAC リン脂質誘導体による肺転移癌治療
- CNDACリン脂質誘導体含有RES回避リポソームの抗腫瘍効果
- シアル酸を含有しない糖脂質とインフルエンザA型ウイルスの結合
- Therapeutic Efficacy of 5-Fluorouracil Prodrugs Using Endogenous Serum Proteins as Drug Carriers : A New Strategy in Drug Delivery System
- Highly Branched Oligosaccharides Produced by the Transglycosylation Reaction of Neopullulanase
- 魚類に対する環境汚染化学物質の蓄積並びに影響の淡水と海水における相違(第2報)クロルデン及びペンタクロルフェノールの淡水馴化ボラによる検討
- 魚類に対する環境汚染化学物質の蓄積並びに影響の淡水と海水における相違(第1報)クロルデン及びペンタクロルフェノールの海水馴化ティラピアによる検討
- Neopullulanase Exhibits Distinct Specificity toward Amylose and Amylopectin
- Therapeutic Effect of Reticuloendothelial System (RES)-Avoiding Liposomes Containing a Phospholipid Analogue of 5-Fluorouracil, Dipalmitoylphosphatidylfluorouridine, in Meth A Sarcoma-Bearing Mice
- 環境汚染化学物質の魚類の鰓に対する影響
- Mutagenicity of Dimethylated Metabolites of Inorganic Arsenics
- 温度感受性リポソームによる腫瘍壊死因子(TNF)の組織特異的デリバリーのための基礎研究
- 4-(Benzoylindolizinyl)butyric Acids ; Novel Nonsteroidal Inhibitors of Steroid 5α-Reductase. III.^
- 4-(1-Benzoylindol-3-yl)butyric Acids and FK143 : Novel Nonsteroidal Inhibitors of Steroid 5α-Reductase (II)
- (1-Benzylinodole-3-yl)alkanoic Acids : Novel Nonsteroidal Inhibitors of Steroid 5α-Reductase (I)
- Total Synthesis of WS9326A, a Potent Tachykinin Antagonist from Streptomyces violaceoniger
- Synthesis of 3,4-Dimethoxyphenyl β-D-Glucopyranoside and Its Related Glycosides by Cultured Plant Cells
- Glucosylation of Capsaicin by Cell Suspension Cultures of Coffea arabica
- Glucosylation of Vanillin by Cultured Plant Cells
- A New Method for Precipitation of Various Glucosides with Cyclodextrin Glucano-transferase
- RGD構造類似体アルギニルアミノヘキサン酸およびその修飾リポソームによる癌転移抑制
- 馬鈴薯澱粉由来リン酸化オリゴ糖の生産と応用
- Novel Transglucosylating Reaction of Sucrose Phosphorylase to Carboxylic Compounds Such as Benzoic Acid(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)
- Syntheses of α-Arbutin-α-Glycosides and Their Inhibitory Effects on Human Tyrosinase(Enzymology, Protein Engineering, and Enzyme Technology)
- Inhibitory Effects of α-Arbutin on Melanin Synthesis in Cultured Human Melanoma Cells and a Three-Dimensional Human Skin Model (Pharmacology)
- Absorbability of Calcium from Calcium-bound Phosphoryl Oligosaccharides in Comparison with That from Various Calcium Compounds in the Rat Ligated Jejunum Loop(Food & Nutrition Science)
- Syntheses of Arbutin-α-glycosides and a Comparison of Their Inhibitory Effects with Those of α-Arbutin and Arbutin on Human Tyrosinase
- Substrate Selectivity in Aspergillus niger KU-8 Acid Phosphatase II Using Phosphoryl Oligosaccharides
- A Novel Acid Phosphatase from Aspergillus niger KU-8 That Specifically Hydrolyzes C-6 Phosphate Groups of Phosphoryl Oligosaccharides
- Effect of Phosphoryl Oligosaccharides on Iron Solubility under Neutral Conditions
- Studies of Phosphoryl Oligosaccharides Prepared from Potato Starch〔含 質疑応答〕 (糖質関連酵素化学シンポジウム)
- The Structures of Phosphoryl Oligosaccharides Prepared from Potato Starch
- サポニンによる好中球の活性化
- 茶葉カテキン類のインフルエンザウイルスに対する不活化作用
- ALS 阻害型除草剤 KIH-2023 のラットにおける代謝
- DNA-Strand Breaks Induced by Dimethylarsinic Acid, a Metabolite of Inorganic Arsenics, Are Strongly Enhanced by Superoxide Anion Radicals
- C114 新規除草剤 KIH-2023 に関する報告(第 1 報) : ラットにおける代謝
- リポソーム化 RGD による癌転移抑制
- Functional role of sialyl lewis X and fibronectin-derived RGDS peptide analogue on tumor cell arrest in lungs followed by extravasation.
- PETによりがんの転移過程を観察する
- 転移性癌細胞の生体内動態におけるインテグリンの関与 : PETを用いた解析
- 高分子デリバリーを目的とした温度感受性リポソームの開発
- Asymmetric Synthesis of a Selective Endothelin A Receptor Antagonist
- 磁気共鳴映像法 (MRI) における悪性腫瘍の診断精度を高めるための造影剤の開発
- Asymmetric Synthesis of an Endothelin Receptor Antagonist
- A Sports Drink Based on Highly Branched Cyclic Dextrin Generates Few Gastrointestinal Disorders in Untrained Men during Bicycle Exercise
- Antidiabetic Effect of Glycyrrhizin Genetically Diabetic KK-A^y Mice
- Enhancement of Swimming Endurance in Mice by Highly Branched Cyclic Dextrin
- Effect of Glycolipid Fraction on Fat Bloom in Dark and Milk Chocolates
- Preparation of Glyceroglycolipids from Pumpkin and Their Effects on Polymorphic Transformation of Cocoa Butter
- A Method for Preparation of Soluble Carthamin, Red Pigment from Safflower, Using Glycosyl Hesperidin
- Effects of Salt and pH on Property of Emulsion Prepared with Monolaurin Monoglucoside
- Synthesis of Monoacylglycerol Monoglucoside by Rice α-Glucosidase and Its Foaming Power
- Lowering Effect of Phenolic Glycosides on the Rise in Postprandial Glucose in Mice
- Glucosylation of Acetic Acid by Sucrose Phosphorylase
- Effects of Glyceroglycolipids Prepared from Various Natural Materials on Polymorphic Transformation of Cocoa Butter
- Acceptor Specificity of Cyclodextrin Glucanotransferase from an Alkalophilic Bacillus Species and Synthesis of Glucosyl Rhamnose
- Synthesis of Neohesperidin Glycosides and Naringin Glycosides by Cyclodextrin Glucanotransferase from an Alkalophilic Bacillus Species
- Cyclic α-1,4-Glucan Formation by Bacterial α-Amylases
- 無機ヒ素化合物の発癌性並びにその誘発機構
- 無機ヒ素のメチル化代謝と遺伝子傷害性ならびに腫瘍誘発性
- Glucosylation of Caffeic Acid with Bacillus subtilis X-23 α-Amylase and a Description of the Glucosides
- Transglycosylation to Hesperidin by Cyclodextrin Glucanotransferase from an Alkalophilic Bacillus Species in Alkaline pH and Properties of Hesperidin Glycosides
- Acceptor Specificity in the Glucosylation Reaction of Bacillus subtilis X-23 α-Amylase towards Various Phenolic Compounds and the Structure of Kojic Acid Glucoside
- Purification and Some Properties of α-Amylase from Bacillus subtilis X-23 That Glucosylates Phenolic Compounds Such as Hydroquinone
- Puritication and Characterization of Cyclodextrin Glucanotransferase from an Alkalophilic Bacillus Species and Transglycosylation at Alkaline pHs
- Glucosylation of Acetic Acid by Sucrose Phosphorylase
- 日本薬学会奨励賞受賞奥直人氏の業績
- Mechanism of Tumor Transport of ^Tc-DL-Homocysteine, a Possible Tumor-Imaging Agent
- ジメチルアルシン酸の還元代謝過程で生ずる活性種の発癌への寄与
- Effct of Reticuloendothelial Blockade on Tissue Distribution of ^Tc-Labeled Synthetic Liposomes in Ehrlich Solid Tumor-Bearing Mice
- Liposomes Prepared from Synthetic Amphiphiles. II. : Their Interaction with Ehrlich Ascites Tumor Cells and Tissue Distribution in Ehrlich Solid Tumor-Bearing Mice
- Liposomes Prepared from Synthetic Amphiphiles. I. : Their Technetium Labeling and Stability
- てんかん発作と脳内亜鉛動態
- ラット脳の発育時における亜鉛代謝と学習との関係
- マウス脳内への亜鉛取り込みにおけるヒスチジンの影響
- ラット脳内へのマンガン取り込みにおけるトランスフェリンの役割
- ジメチルアルシン酸投与マウスにおけるHsp72の誘導について
- トランスフェリン欠損マウスの脳における鉄の取込
- グリアでの鉄輸送におけるトランスフェリンの役割
- 当院における妊婦・新生児の血清および母乳中の亜鉛・銅濃度に関する検討
- ヒ素発癌におけるメチル化代謝物の関与の可能性 : ジメチルヒ素ラジカルの寄与
- ヒ素発癌におけるメチル化代謝物の関与の可能性 : ジメチルヒ素ラジカルの寄与
- ラット脳内におけるマンガン輸送
- 亜鉛の嗅覚路における輸送と嗅覚能との関係
- ラット脳内における亜鉛とマンガンの動態 : 生物学的半減期及び嗅覚機能との関連性
- ラットの線条件に亜鉛及びマンガンを投与した場合の脳内動態
- 癌の発生・増殖時における亜鉛の動態
- ジメチルアルシン酸の還元代謝物による発癌誘発作用
- 3価ジメチルヒ素の酸化分解過程において生成するジメチルヒ素過酸化物による核酸塩基の酸化的傷害機構
- 慢性ヒ素中毒患者由来の皮膚癌試料に対する組織化学的評価
- ジメチルヒ素によるHsp72の肺胞II型上皮細胞への特異的分布の in vivo での検討
- ジメチルアルシン酸投与によるマウス組織特異的8-oxodGの生成
- マウス皮膚発癌実験モデルを利用した無機ヒ素代謝物の発癌影響評価
- ラット嗅覚路におけるマンガンの動態と役割
- シナプス神経伝達における亜鉛の役割 : 学習・記憶との関係において
- マンガンのマウス大脳基底核集積機構に関する研究
- Neopullulanase Exhibits Distinct Specificity toward Amylose and Amylopectin