Inhibitory Effects of α-Arbutin on Melanin Synthesis in Cultured Human Melanoma Cells and a Three-Dimensional Human Skin Model (Pharmacology)

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概要

• 論文の詳細を見る

• We studied the inhibitory effects of 4-hydroxyphenyl α-glucopyranoside (α-arbutin) on melanogenesis in cultured human melanoma cells, HMV-II, and in a three-dimensional cultured human skin model. α-Arbutin showed no inhibitory effect on HMV-II cell growth at a concentration below 1.OmM. Melanin synthesis in cells treated with α-arbutin at 0.5mM decreased to 76% of that in non-treated cells. The cellular tyrosinase activity of HMV-II cells also significantly decreased, while the expression of its mRNA was not affected. Melanin synthesis in a human skin model was also evaluated by the macro- and microscopic observation of its pigmentation as well as by quantitative measurements of melanin. Treatment of the human skin model with 250μg of α-arbutin did not inhibit cell viability, while melanin synthesis was reduced to 40% of that in the control. These results indicate that α-arbutin is an effective and safe ingredient for skin-lightening.

• 公益社団法人日本薬学会の論文
• 2004-04-01

著者

• SUGIMOTO Kazuhisa

  Biochemical Research Laboratory, Ezaki Glico Co., Ltd.

• NISHIMURA Takahisa

  Biochemical Research Laboratory, Ezaki Glico Co., Ltd.

• KURIKI Takashi

  Biochemical Research Laboratory, Ezaki Glico Co., Ltd.

• TO-O Kenji

  Health Science Laboratory, Ezaki Glico

• NOMURA Koji

  Biochemical Research Laboratory, Ezaki Glico

• Kuriki T

  Health Science Laboratory Ezaki Glico

• Nomura K

  Biochemical Research Laboratory Ezaki Glico

• Kometani T

  Biochemical Res. Lab. Ezaki Glico Co. Ltd.

• Kuriki T

  Ezaki Glico Co. Ltd. Osaka Jpn

• SUGIMOTO KENJI

  Laboratory of Applied Molecular Biology, Division of Applied Biochemistry, Graduate School of Agricu

• To-o Kenji

  Health Science Laboratory Ezaki Glico

• Kuriki Takashi

  Biochemical Research Laboratory Ezaki Glico

• Kuriki Takashi

  Biochemical Research Laboratories Ezaki Glico Co. Ltd.

• Sugimoto Kazuhisa

  Biochemical Research Laboratory Ezaki Glico

• Sugimoto Kazuhisa

  Department Of Applied Biological Chemistry College Of Agriculture University Of Osaka Prefecture

• Nishimura Takahisa

  Biochemical Research Laboratory Ezaki Glico Co. Ltd.

• Nishimura Takahisa

  Research Planning Division Ezaki Glico

• Nishimura Takahisa

  Department Of Agricultural Chemistry College Of Agriculture University Of Osaka Prefecture

• Sugimoto Kenji

  江崎グリコ生物化学研究所

• Nishimura T

  Central Research Laboratories Kissei Pharmaceutical Co. Ltd.

• Nomura Koji

  Biochemical Research Laboratory Ezaki Glico

• Kuriki T

  Biochemical Research Laboratory Ezaki Glico

• Sugimoto Kenji

  Laboratory Of Applied Molecular Biology Division Of Applied Biochemistry Graduate School Of Agricult

• Nomura K

  Institute Of Agriculture And Forestry University Of Tsukuba

• Sugimoto Kenji

  Laboratory Of Applied Molecular Biology Department Of Applied Biochemistry Osaka Prefecture Universi

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