Optimization of Operating Conditions in a High-Shear Mixer Using DEM Model : Determination of Optimal Fill Level
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概要
- 論文の詳細を見る
For the purpose of evaluating optimal fill level of starting materials in a high-shear mixer, discrete element method (DEM) simulation was conducted to visualize kinetic status between particles. The simulation results obtained by changing fill levels were used to determine solid fraction of particles, particle velocity, particle velocity vector, and kinetic energy and discuss the flow pattern. Optimal fill level was obtained from the information on these matters. It was pointed out that understanding the kinetic energy between particles in an agitating vessel was effective in determining the optimal fill level. Granulation experiment was conducted to validate the optimal fill level obtained by the simulation, confirming the good agreement between these two results. It was pointed out that determination of kinetic energy between particles through the simulation was effective in obtaining an index of the kinetic status of particles. Further, it was confirmed that the simulation could provide more information than conventional granulation experiments could provide and also helpful in optimizing the operating conditions.
- 公益社団法人日本薬学会の論文
- 2002-12-01
著者
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Nishimura T
Central Research Laboratories Kissei Pharmaceutical Co. Ltd.
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TERASHITA Keijiro
Department of Engineering, Osaka Prefecture University
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NISHIMURA Takehiko
Department of Engineering, Osaka Prefecture University
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NATSUYAMA Susumu
POWREX Co.,Ltd.
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Nishimura T
Department Of Engineering Osaka Prefecture University
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Natsuyama Susumu
Powrex Co. Ltd.
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Terashita Keijiro
Department Of Engineering Osaka Prefecture University
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Terashita Keijiro
Department Of Chemical Engineering Osaka Prefecture University
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