Preparation of Antipyretic Analgesic by Direct Compression and Its Evaluation

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概要

• 論文の詳細を見る

• Direct compression is able to produce tablets at a lower cost than wet granulation and tableting method, due to a fewer items of process validation. In this study, acetaminophen was used as a medicine with various granular diameters to formulate tablets by direct compression, thus evaluating their physical properties. Consequently, direct compression was found effective in formulating tablets with excellent physical properties, with the granular diameter taken into account. It was confirmed that tablets produced by direct compression were similar in physical properties in tablets produced by wet granulation and tableting method. Further, it was suggested that use of a dry-type binder would make it possible to provide a tablet having higher content of the medicine with excellent physical properties.

• 公益社団法人日本薬学会の論文
• 2002-12-01

著者

• TERASHITA Keijiro

  Department of Engineering, Osaka Prefecture University

• Terashita Keijiro

  Department Of Engineering Osaka Prefecture University

• Imamura K

  Wakunaga Pharmaceutical Co. Ltd. Hiroshima Jpn

• TERASHITA Keijiro

  Osaka Prefecture University, Department of Engineering

• IMAMURA Keisuke

  Osaka Prefecture University, Department of Engineering

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