Modification of Thermal Response of Chlorella ellipsoidea by Deuteration

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概要

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• The isotope effect of deuterium (D) on cellular thermo-response, one of the major cell functions, was pursued by using deuterated Chlorella ellipsoidea which was grown in D_2O medium and deuterated proportionally to the concentration of D_2O in the medium. The deuterated Chlorella (D-Chlorella) cells heat-treated at 43℃ in H_2O medium were more heat-sensitive than control Chlorella (H-Chlorella) cultured in H_2O medium. The D-Chlorella cells grown in higher mol% D_2O were more heat-sensitive than those grown in lower mol% D_2O. On the other hand, both the D- and H-Chlorella cells heat-treated at 43℃ in D_2O medium were more heat-resistant than in H_2O medium. The degree of heat resistance was linearly proportional to the concentration of D_2O in the medium. These results suggest that D in the medium and cells had two opposite effects on Chlorella; deuteration of poorly exchageable regions of biomolecules in the cells made Chlorella heat-sensitive, and both D_2O in the medium and D in easily exchangeable regions caused Chlorella to be heat-resistant.

• 社団法人日本薬学会の論文
• 1989-11-25

著者

• 海野 けい子

  静岡県立大学 短大部

• 岡田 昌二

  静岡県大薬

• 海野 けい子

  Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka

• 岡田 昌二

  Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka

• 棒葉 繁紀

  Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka

• 棒葉 繁紀

  Department Of Radiobiochemistry School Of Pharmaceutical Sciences University Of Shizuoka

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