Differential Radioactivity Uptake from ^<14>C-Labeled D-and L-Leucine by the Pancreas of Animals pretreated with Pancreatitis-causing Agents

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It was demonstrated by in vivo and in vitro radioactivity determinations and autoradiographic studies that the pancreas of animals pretreated with carbon tetrachloride or ethionine exhibited a reduced radioactivity uptake upon ^<14>C-labeled L-leucine administration, whereas no significant decrease was observed in uptake of D-leucine. This uptake decrease from radioactive L-leucine in the pancreas of the treated animals is suggested to be due to inhibitions of protein synthesis and active membrane transport in the pancreas. The present investigations suggest that comparative studies of amino acid uptake by the pancreas using ^<11>C-labeled D-and L-amino acids such as leucine might be more useful in the detection and assessment of pancreatitis by nuclear imaging of the pancreas than the use of L-amino acids alone or DL-amino acid racemates.
社団法人日本薬学会の論文
1982-07-25