Exit Characteristics of ^<14>C-Labeled Leucine from Ehrlich Ascites Tumor Cells

概要

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The present investigation was undertaken to examine the exit mechanisms of D- and L-leucine compared with those of D- and L-alanine. The exit processes of D- and L-amino acids appear to consist mainly of an unsaturable process under physiological conditions. The exit velocities of D-leucine and D-alanine were slower than those of the corresponding L-amino acid under various conditions. A marked increase in the exit velocity of L-leucine was observed in the presence of gramicidin D. This is assumed to be due to the operation of an Na^+-dependent carrier process. On the other hand, the exit of D-leucine was not accelerated, suggesting that the exit of D-leucine is little mediated by an Na^+-dependent process, though the influx of D-leucine was well as that of L-leucine was partly mediated by an Na^+-dependent process.
公益社団法人日本薬学会の論文
1981-06-25