Nonsteroidal Antiinflammatory Agents. IV. Syntheses of Pyridobenzoxepin, Pyridobenzothiepin and Their Acetic Acid Derivatives
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概要
- 論文の詳細を見る
As part of a search for new antiinflammatory agents, some new tricyclic compounds and their acetic acid derivatives were prepared. Pyrido [2,3-c] [1] benzoxepin-5 (11H)-one (4a) and pyrido [3,2-c] [1] benzoxepin-11 (5H)-one (10a) and their thiepin analogs (4b, 10b) were synthesized by cyclization of the corresponding pyridinecarboxylic acid derivatives (3a, 3b, 9a and 9b) with polyphosphoric acid (PPA). The acetic acid derivatives (12a-b) of 4a-b were prepared via methyl derivatives (14a-b) of 4a-b. Their antiinflammatory activities were less potent than those of the corresponding dibenz [b, e] oxepin- and dibenz-[b, e] thiepinacetic acids.
- 公益社団法人日本薬学会の論文
- 1981-12-25
著者
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田川 博昭
Research Institute, Daiichi Seiyaku Co., Ltd.
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石川 文義
Research Institute, Daiichi Seiyaku Co., Ltd.
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石川 文義
Research Institute Daiichi Seiyaku Co. Ltd.
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田川 博昭
Exploratory Research Laboratories I Daiichi Pharmaceutical Co. Ltd.
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久保 志郎
Research Institute, Daiichi Seiyaku Co., Ltd.
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久保 志郎
Research Institute Daiichi Seiyaku Co. Ltd.
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