3,4-Dihydrothienopyrimidines. II. Synthesis and Sodium Borohydride Reduction of 2-Substituted 4-Chloro- and 4-Unsubstituted-thieno [2,3-d] pyrimidines
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概要
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The synthesis and sodium borohydride reduction of 4-chloro-(1) and 4-unsubstituted-(3) 5,6,7,8-tetrahydro [1] benzothieno [2,3-d] pyrimidines, substituted with various groups, such as chloro, hydrogen, methyl, phenyl, amino, ethoxy, methylthio, methylsulfinyl and mesyl, at position 2,are described. In the reduction of 1,the 2-chloro and 2-methyl-sulfinyl derivatives only gave the corresponding 3,4-dihydro derivatives. The compounds 3,except for the 2-phenyl, 2-amino and 2-ethoxy derivatives, were reduced to give the corresponding 3,4-dihydro derivatives. The reduction was promoted by the presence of an electron withdrawing group at position 2. A 2-or 4-mesyl group was eliminated in the course of the 3,4-dihydrogenation.
- 公益社団法人日本薬学会の論文
- 1982-01-25
著者
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石川 文義
Research Institute, Daiichi Seiyaku Co., Ltd.
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山口 等
Research Institute Daiichi Pharmaceutical Co. Ltd.
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石川 文義
Research Institute Daiichi Seiyaku Co. Ltd.
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