Cyclic Guanidines. VI. Synthesis of Hypoglycemic Tricyclic Guanidines

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概要

• 論文の詳細を見る

• Synthesis of linear and angular tricyclic guanidine derivatives, imidazo- or pyrimido-[2,1-b]- or [1,2-a] quinazoline derivatives, is described. Cyclization of 2-(ω-chloroalkyl)-4-phenyl-3,4-dihydroquinazolines (9) gave two isomers and their isolation was troublesome. 2-Aminobenzhydrylaminoalkanols (10) obtained from 2-aminobenzophenone (5) were converted to linear tricyclic guanidine derivatives (3,12,13,14,15), and other tricyclic compounds (22 and 24) containing an oxygen or a sulfur atom. Reaction of 2-benzoylaminoalkanols (26) obtaired from (5) also gave angular products. Most of the tricyclic guanidine derivatives showed a hypoglycemic activity.

• 社団法人日本薬学会の論文
• 1979-04-25

著者

• 東 邦雄

  Drug Delivery System Institute Ltd.

• 東 邦雄

  Research Institute, Daiichi Seiyaku Co., Ltd.,

• 小笹山 瑛

  Research Institute, Daiichi Seiyaku Co., Ltd.

• 石川 文義

  Research Institute, Daiichi Seiyaku Co., Ltd.

• 石川 文義

  Research Institute Daiichi Seiyaku Co. Ltd.

• 小笹山 瑛

  第一製薬

• 小笹山 瑛

  Research Institute Daiichi Seiyaku Co. Ltd.

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