Studies of Nucleosides and Nucleotides. XXIII. A Versatile Method for Replacement of 6-Hydroxyl Group of Purine Nucleoside.

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概要

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• 2', 3'-O-Isopropylidene-5'-O-benzoylinosine and 2', 3', 5'-tri-O-benzoylinosine were reacted with N, N-dimethylformamide-thionyl chloride complex in chloroform solution. Resulting 6-chloro compound was further reacted with morpholine, dimethylamine and thiourea to afford 6-morpholino-, 6-dimethylamino-and 6-mercapto-derivative of 9-β-D-ribofuranosylpurine in a good overall yield.

• 公益社団法人日本薬学会の論文
• 1964-03-25

著者

• 石川 文義

  Research Institute Daiichi Seiyaku Co. Ltd.

• 池原 森男

  Faculty Of Pharmaceutical Sciences Osaka University

• 宇野 準

  Faculty of Pharmaceutical Sciences, School of Medicine, Hokkaido University

• 石川 文義

  Faculty of Pharmaceutical Sciences, School of Medicine, Hokkaido University, Sapporo, Hokkaido.

関連論文

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