Cyclic Guanidines. VII. Structure-Activity Relationships of Hypoglycemic Cyclic Guanidines
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概要
- 論文の詳細を見る
The hypoglycemic activity and physico-chemical properties (pK_a, log P) of cyclic guanidines were measured. Qualitative structure-activity relationships were investigated in various mono-, bi-, and tricyclic guanidines and it became apparent that compounds which have a bulky group and a pK_a value between 8-11 showed potent activity. It was possible to correlate hypoglycemic activity with the pK_a values and partition coefficients of cyclic guanidines.
- 公益社団法人日本薬学会の論文
- 1979-07-25
著者
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小笹山 瑛
Research Institute, Daiichi Seiyaku Co., Ltd.
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石川 文義
Research Institute, Daiichi Seiyaku Co., Ltd.
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石川 文義
Research Institute Daiichi Seiyaku Co. Ltd.
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小笹山 瑛
第一製薬
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小笹山 瑛
Research Institute Daiichi Seiyaku Co. Ltd.
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